| 100% | GEORGELAZENBY | 13 | Youngest actor to play 16-Across (2 wds.) |
| 64% | MATTSMITH | 9 | Eleventh actor to play the lead role in 15-Across (2010-2013): 2 wds. |
| 64% | DAVIDTENNANT | 12 | Tenth actor to play the lead role in 15-Across (2005-2010): 2 wds. |
| 64% | PETERCAPALDI | 12 | Twelfth actor to play the lead role in 15-Across, starting in 2013: 2 wds. |
| 63% | CARROLLOCONNOR | 14 | Actor who played Archie on 16-Across: 2 wds. |
| 62% | TOMHOLLAND | 10 | Actor who plays Spider-Man in 16-Across: 2 wds. |
| 62% | DONADAMS | 8 | Actor who played Agent 86 on 16-Across: 2 wds. |
| 61% | MICHAELKEATON | 13 | Actor who plays Vulture, the villain in 16-Across: 2 wds. |
| 58% | JAMIEFOXX | 9 | "Ray" actor who plays Little John in 16-Across: 2 wds. |
| 57% | TODDBRIDGES | 11 | Actor who played 32-Across: 2 wds. |
| 57% | GARYCOLEMAN | 11 | Actor who played 30-Across: 2 wds. |
| 56% | FERDIASHAW | 10 | Young actor who plays the title character in the 2020 movie "Artemis Fowl": 2 wds. |
| 56% | COREYHAIM | 9 | "License to Drive" actor who played younger brother Sam in the 1987 vampire movie "The Lost Boys": 2 wds. |
| 56% | BOBBYCANNAVALE | 14 | "Boardwalk Empire" actor who plays husband Dean on 16-Across: 2 wds. |
| 54% | TONYTODD | 8 | "Final Destination" actor who plays the title role in 16-Across: 2 wds. |
| 54% | ANTHONYHOPKINS | 14 | "The Father" actor who played physician Frederick Treves in 16-Across: 2 wds. |
| 54% | CONNIENIELSEN | 13 | Actor playing 36 across in the upcoming movie "Wonder Woman": 2 wds. |
| 54% | SEANCONNERY | 11 | First actor to play James Bond on the big screen (2 wds.) |
| 52% | RAMONRODRIGUEZ | 14 | "Charlie's Angels" actor who plays the title role on 16-Across: 2 wds. |
| 51% | OAKESFEGLEY | 11 | "Pete's Dragon" actor who plays young Theo in 30-Across: 2 wds. |
| 51% | ERICBANA | 8 | Actor who played 32-Across in a 2003 film: 2 wds. |
| 51% | EDWARDNORTON | 12 | Actor who played 32-Across in a 2008 film: 2 wds. |
| 50% | JOHNNYDEPP | 10 | Actor who plays 26-/37-Across in "Black Mass": 2 wds. |
| 50% | HARRISONFORD | 12 | Second actor to play the CIA operative played by Chris Pine in "Jack Ryan: Shadow Recruit" (2 wds.) |
| 50% | DENNISQUAID | 11 | "Flight of the Phoenix" actor who plays the title role in 16-Across: 2 wds. |
| 50% | GENEWILDER | 10 | Actor who played 31-/34-Across in a 1971 film: 2 wds. |
| 50% | JOHNNYDEPP | 10 | Actor who played 31-/34-Across in a 2005 film: 2 wds. |
| 50% | IAINARMITAGE | 12 | Actor who plays child prodigy Sheldon Cooper on "Young Sheldon": 2 wds. |
| 50% | JOHNGOODMAN | 11 | Actor returning to play Dan Conner on "Roseanne" (2 wds.) |
| 49% | JASONMOMOA | 10 | Actor who plays Aquaman in 30-Across: 2 wds. |