| 100% | MARGOTROBBIE | 12 | "Babylon" actress who plays the title character in "Barbie": 2 wds. |
| 83% | SARAHPAULSON | 12 | "American Horror Story" actress who plays the title character in Netflix's "Ratched": 2 wds. |
| 81% | RACHELMCADAMS | 13 | "Doctor Strange" actress who plays the title character's mom in 33-/49-Across: 2 wds. |
| 76% | TOMHARDY | 8 | "Inception" actor who plays the title character in "Venom": 2 wds. |
| 75% | LINDALAVIN | 10 | Actress who played the title character on the sitcom "Alice": 2 wds. |
| 74% | SUSANSARANDON | 13 | Actress who played Louise, one of the title characters on the run in 1991's "Thelma & Louise": 2 wds. |
| 74% | RENEEZELLWEGER | 14 | Actress who returns to play the title character in "Bridget Jones: Mad About the Boy": 2 wds. |
| 73% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 73% | FERDIASHAW | 10 | Young actor who plays the title character in the 2020 movie "Artemis Fowl": 2 wds. |
| 73% | PETERDINKLAGE | 13 | "Game of Thrones" actor who plays the title character in "The Toxic Avenger": 2 wds. |
| 73% | EDIEFALCO | 9 | "The Sopranos" actress who played the title character on "Nurse Jackie": 2 wds. |
| 73% | LILYCOLLINS | 11 | Actress who plays the title character on 46-Across (2 wds.) |
| 72% | OLIVIAMUNN | 10 | "The Predator" actress who plays the title role in "Violet": 2 wds. |
| 70% | CAMILLERAZAT | 12 | Actress who plays the title character's new friend on 46-Across (2 wds.) |
| 70% | LOUISAHARLAND | 13 | "Derry Girls" actress who plays the title character on 44-Across (2 wds.) |
| 69% | JAMESMCAVOY | 11 | "X-Men: Apocalypse" star who played the title character of 28-Across in a 2015 movie: 2 wds. |
| 69% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 69% | BARBARABARRIE | 13 | "Breaking Away" actress who played the title character's Nana on 46-Across (2 wds.) |
| 69% | KARENFUKUHARA | 13 | "Suicide Squad" actress who voices the title character in 14-/32-Across: 2 wds. |
| 68% | JULIAROBERTS | 12 | "Pretty Woman" actress who played the title role in 2000's "Erin Brockovich": 2 wds. |
| 68% | SARAHPAULSON | 12 | "American Horror Story" actress who plays the title character, 46-Across, on a Netflix miniseries (2 wds.) |
| 68% | BROOKESHIELDS | 13 | "The Blue Lagoon" actress who played the title character on 46-Across (2 wds.) |
| 68% | JULIAGARNER | 11 | "Ozark" actress who plays the title con artist in 30-Across (2 wds.) |
| 68% | HELENMIRREN | 11 | "The Queen" actress who plays the title role in "Golda" (2 wds.) |
| 67% | BRIELARSON | 10 | Actress who plays the character of Carol Danvers, a former U.S. Air Force pilot in "Captain Marvel": 2 wds. |
| 67% | FAYEDUNAWAY | 11 | "Network" actress who played the fiancée of Paul Newman's architect character in "The Towering Inferno": 2 wds. |
| 67% | KATEY | 5 | With 35-Across, "Sons of Anarchy" actress who plays the title character in "Rebel" |
| 67% | WHITE | 5 | Carol —, actress who played the title character in 1966 BBC TV play Cathy Come Home |
| 66% | GINARODRIGUEZ | 13 | Actress who plays the title role on 15-Across: 2 wds. |
| 66% | KENNEDYMCMANN | 13 | Actress who plays the title role on "Nancy Drew": 2 wds. |