| 100% | JOHNLITHGOW | 11 | "Dexter" actor who graduated with honors from Harvard as a History and Literature major: 2 wds. |
| 61% | TOMMYLEEJONES | 13 | "Lincoln" actor who graduated with honors from Harvard as an English major: 3 wds. |
| 55% | MIRASORVINO | 11 | "Mighty Aphrodite" actress who graduated with honors from Harvard as an East Asian Studies major: 2 wds. |
| 36% | CHRISPERFETTI | 13 | "Looking" actor who plays a history teacher and ally of 15-Across: 2 wds. |
| 35% | ASHTONKUTCHER | 13 | Actor who was part of television shows such as "Two and a Half Men" and "That '70s Show": 2 wds. |
| 35% | CHARLIESHEEN | 12 | "Two and a Half Men" actor who was a roastee on Comedy Central Roast with Seth MacFarlane as the roast master: 2 wds. |
| 35% | ROWANATKINSON | 13 | Actor who voiced Zazu, a hornbill in "The Lion King" and is best known for his role as Mr. Bean: 2 wds. |
| 35% | BOBSAGET | 8 | "Fuller House" actor who was a roastee on Comedy Central Roast with John Stamos as the roast master: 2 wds. |
| 35% | BOBODENKIRK | 11 | "Better Call Saul" actor who auctioned a dinner with himself and David Cross to benefit the WGA strike: 2 wds. |
| 34% | GEORGEMURPHY | 12 | American actor who served as the U.S. Senator from California and was also included in the Hollywood Walk of Fame: 2 wds. |
| 33% | BRADLEYCOOPER | 13 | Actor who starred in and made his directorial debut with 2018's "A Star Is Born": 2 wds. |
| 33% | JAMESMARSDEN | 12 | "27 Dresses" actor who has acted as Marvel superhero in "X-Men" and was also a part of the DC movie "Superman Returns": 2 wds. |
| 33% | ELISABETHSHUE | 13 | "CSI" actress who graduated from Harvard: 2 wds. |
| 32% | ALANRICKMAN | 11 | Actor who played Professor Snape and was a misunderstood character in "Harry Potter" series: 2 wds. |
| 32% | JOSEPHCOTTEN | 12 | Actor who played a reporter and friend of the title character in 17-Across: 2 wds. |
| 31% | SETHMACFARLANE | 14 | Actor who starred in and made his directorial debut with 2012's "Ted": 2 wds. |
| 31% | HUGHLAURIE | 10 | "House" actor who plays keyboards and sings in Band From TV: 2 wds. |
| 31% | MATTLEBLANC | 11 | "Friends" actor who plays Adam Burns on "Man With a Plan": 2 wds. |
| 31% | BILLYCRYSTAL | 12 | "When Harry Met Sally ..." actor who received a 2023 Kennedy Center Honor: 2 wds. |
| 31% | GARRETTMORRIS | 13 | "2 Broke Girls" actor who was honored with a star on the Hollywood Walk of Fame in 2023 (2 wds.) |
| 31% | GEORGECLOONEY | 13 | Actor who starred in and made his directorial debut with 2002's "Confessions of a Dangerous Mind": 2 wds. |
| 31% | TOMMYLEE | 8 | ___ Jones, actor from "Lonesome Dove" who graduated from Harvard University in 1969: 2 wds. |
| 31% | JAMESFRANCO | 11 | "127 Hours" actor who earned a master's in writing from Columbia University: 2 wds. |
| 31% | ALPACINO | 8 | "Dog Day Afternoon" actor who is a Grammy away from completing the EGOT: 2 wds. |
| 31% | AUSTINSTOWELL | 13 | "Bridge of Spies" actor who stars as a young Jethro on "NCIS: Origins": 2 wds. |
| 31% | KEVINNEALON | 11 | "Weeds" actor who plays Adam's brother Don on "Man With a Plan": 2 wds. |
| 30% | YULBRYNNER | 10 | Actor who won a Tony and an Oscar for playing King Mongkut in "The King and I": 2 wds. |
| 30% | BRUCEWILLIS | 11 | Actor who made his mark as an action hero 30 years ago with the hit "Die Hard": 2 wds. |
| 30% | REDDFOXX | 8 | Actor who starred on "Sanford and Son," a sitcom developed by Norman Lear (who turns 100 today): 2 wds. |
| 30% | ALEXNEWELL | 10 | Actor who won a Tony in 2023 for their role as Lulu in the Broadway musical "Shucked": 2 wds. |