| 100% | OLIVERPLATT | 11 | "Huff" actor who plays Dr. Daniel Charles on "Chicago Med": 2 wds. |
| 62% | TORREYDEVITTO | 13 | "Army Wives" actress who plays Dr. Natalie Manning on "Chicago Med": 2 wds. |
| 60% | KELSEYGRAMMER | 13 | Actor who played Dr. Frasier Crane on "Frasier": 2 wds. |
| 59% | MARKHARMON | 10 | "NCIS" actor who played Dr. Robert Caldwell on "St. Elsewhere": 2 wds. |
| 57% | OMARMILLER | 10 | "CSI: Miami" actor who plays Charles on "Ballers": 2 wds. |
| 57% | SETHGREEN | 9 | Actor who played Daniel "Oz" Osbourne on "Buffy the Vampire Slayer": 2 wds. |
| 56% | JOHNMALKOVICH | 13 | "The New Pope" actor who plays Dr. Adrian Mallory on "Space Force": 2 wds. |
| 56% | LISAEDELSTEIN | 13 | Actress who plays Dr. Cuddy on "House, M.D.": 2 wds. |
| 55% | MARTINFREEMAN | 13 | "The Hobbit" actor who plays Dr. Watson on the BBC's "Sherlock": 2 wds. |
| 55% | RONLEIBMAN | 10 | "Norma Rae" actor who played Rachel's father, Dr. Leonard Green, on "Friends": 2 wds. |
| 55% | ROBERTSEAN | 10 | With 25-Across, actor who played Dr. James Wilson (based on 47-Across) on the Fox series "House": 2 wds. |
| 55% | TIMROTH | 7 | "Pulp Fiction" actor who played Dr. Cal Lightman on the Fox series "Lie To Me": 2 wds. |
| 54% | JESSESPENCER | 12 | "House" actor who plays Capt. Matthew Casey on "Chicago Fire": 2 wds. |
| 54% | HARRISONFORD | 12 | "1923" actor who plays Dr. Paul Rhoades on "Shrinking" (2 wds.) |
| 53% | RYANEGGOLD | 10 | "The Blacklist" actor who plays Dr. Max Goodwin on "New Amsterdam" (2 wds.) |
| 53% | OMIDABTAHI | 10 | "American Gods" actor who plays Dr. Pershing on "The Mandalorian" (2 wds.) |
| 53% | TEE | 3 | Actor Brian who plays Dr. Ethan Choi on "Chicago Med" |
| 52% | JAMESBROLIN | 11 | "Life in Pieces" actor who played Dr. Steve Kiley on 30-Across (2 wds.) |
| 52% | KENNETHCHOI | 11 | Actor who played Chester Ming on "The Wolf of Wall Street" and portrays the role of Judge Lance Ito in "American Crime Story" : 2 wds. |
| 51% | TAYLORKINNEY | 12 | "The Vampire Diaries" actor who plays Lt. Kelly Severide on "Chicago Fire": 2 wds. |
| 51% | STEVEMARTIN | 11 | "Dirty Rotten Scoundrels" actor who plays Charles on "Only Murders in the Building" (2 wds.) |
| 51% | MARKHARMON | 10 | "Chicago Hope" actor who plays Special Agent Leroy Gibbs on "NCIS": 2 wds. |
| 51% | BILLYPORTER | 11 | Actor who plays Pray Tell on "Pose": 2 wds. |
| 51% | CARROLLOCONNOR | 14 | Actor who played Archie on 16-Across: 2 wds. |
| 51% | ANDYKAUFMAN | 11 | Actor who played Latka Gravas on "Taxi": 2 wds. |
| 51% | HARRYMORGAN | 11 | Actor who played Colonel Sherman T. Potter on the 1972-1983 sitcom "M*A*S*H": 2 wds. |
| 50% | SEANGIAMBRONE | 13 | Actor who plays the geeky boy, Adam, on 18-Across: 2 wds. |
| 50% | IAINARMITAGE | 12 | Actor who plays child prodigy Sheldon Cooper on "Young Sheldon": 2 wds. |
| 50% | LARRYHAGMAN | 11 | Actor who played Tony Nelson on "I Dream of Jeannie": 2 wds. |
| 50% | OMAR | 4 | ___ Epps, actor who plays Dr. Eric Foreman on "House, M.D." |