| 100% | OLIVERPLATT | 11 | "The Bear" costar who played Dr. Mark Weller in "Dr. Dolittle": 2 wds. |
| 56% | EDDIEMURPHY | 11 | "Coming to America" actor who played the title role in 1998's "Dr. Dolittle": 2 wds. |
| 55% | JUDELAW | 7 | "Alfie" actor who played Dr. Watson in the movie "Sherlock Holmes": 2 wds. |
| 55% | DIANEKRUGER | 11 | Actress who plays Dr. Abigail Chase in the "National Treasure" films: 2 wds. |
| 55% | TOMMYLEEJONES | 13 | "Men in Black" costar who played Dr. Mark Toland on "One Life to Live": 3 wds. |
| 55% | AARONECKHART | 12 | "The Dark Knight" costar who plays the US president in "London Has Fallen": 2 wds. |
| 55% | DAVECHAPPELLE | 13 | "A Star Is Born" actor who won the Mark Twain Prize in 2019: 2 wds. |
| 54% | JEANHAGEN | 9 | "The Danny Thomas Show" costar who played a vain actress in "Singin' in the Rain": 2 wds. |
| 54% | KEELEYHAWES | 11 | "The Missing" actress who plays Dr. Kira Manning in the "Echoes" spin-off of 18-Across: 2 wds. |
| 54% | JAREDLETO | 9 | "Suicide Squad" actor who plays Dr. Michael Morbius in the upcoming movie "Morbius": 2 wds. |
| 53% | RACHELMCADAMS | 13 | Actress who plays Dr. Christine Palmer in "Doctor Strange in the Multiverse of Madness": 2 wds. |
| 52% | KELSEYGRAMMER | 13 | Actor who played Dr. Frasier Crane in "Frasier" and "Cheers", and hosted the 1998 Grammy Awards: 2 wds. |
| 52% | NATHANFILLION | 13 | "Castle" actor who plays Dr. Jim Pomatter in the film "Waitress" (2 wds.) |
| 51% | ANTHONYRAMOS | 12 | "A Star Is Born" actor who plays Usnavi, the lead character in 18-Across: 2 wds. |
| 51% | RAINNWILSON | 11 | "The Office" actor who plays Dr. Demento in "Weird: The Al Yankovic Story" (2 wds.) |
| 51% | JANELYNCH | 9 | "Glee" costar who played the main character's mother in the 2022 Broadway revival of 15-Across: 2 wds. |
| 51% | FELICITYJONES | 13 | "The Theory of Everything" actress who plays Dr. Sienna Brooks in "Inferno": 2 wds. |
| 50% | NORMMACDONALD | 13 | "Saturday Night Live" comedian who voiced the dog Lucky in "Dr. Dolittle": 2 wds. |
| 50% | DWAYNEJOHNSON | 13 | Actor who plays Dr. Smolder Bravestone in "Jumanji: Welcome to the Jungle" (2 wds.) |
| 50% | NATHANFILLION | 13 | "Castle" actor who plays Dr. Jim Pomatter in the 2007 film "Waitress" (2 wds.) |
| 50% | HEATHLEDGER | 11 | Late Australian-born actor who played the Joker in "The Dark Knight": 2 wds. |
| 50% | JIMCARREY | 9 | "The Mask" actor who plays the villain Dr. Robotnik in the 2020 video-game movie "Sonic the Hedgehog": 2 wds. |
| 50% | ANTHONYRAPP | 11 | "Star Trek: Discovery" actor who played Mark Cohen in the original Broadway cast of "Rent": 2 wds. |
| 50% | DAVECHAPPELLE | 13 | "A Star Is Born" actor who played Reggie Warrington in "The Nutty Professor": 2 wds. |
| 49% | ANNETTEBENING | 13 | "Death on the Nile" actress who plays Dr. Wendy Lawson in the Marvel film "Captain Marvel" (2 wds.) |
| 49% | WALTERMATTHAU | 13 | "The Bad News Bears" actor who played the love interest of Barbra Streisand's character in 1969's "Hello, Dolly!": 2 wds. |
| 49% | LUCYLIU | 7 | "Kill Bill" actress who plays Dr. Watson in CBS's "Elementary": 2 wds. |
| 49% | URSULAANDRESS | 13 | Swiss actress who played the first Bond girl in "Dr. No": 2 wds. |
| 48% | CARRIECOON | 10 | "The Leftovers" actress who plays Callie, the daughter of Dr. Egon Spengler, in "Ghostbusters: Afterlife" (2 wds.) |
| 48% | TIMCURRY | 8 | "Clue" star who played Dr. Frank-N-Furter in "The Rocky Horror Picture Show": 2 wds. |