| 100% | LORNEMICHAELS | 13 | "SNL" producer who won the Mark Twain Prize for American Humor in 2004: 2 wds. |
| 80% | EDDIEMURPHY | 11 | "The Nutty Professor" actor and "SNL" star who won the Mark Twain Prize for American Humor in 2015: 2 wds. |
| 76% | WILLFERRELL | 11 | "Elf" actor and "Saturday Night Live" star who won the Mark Twain Prize for American Humor in 2011: 2 wds. |
| 75% | STEVEMARTIN | 11 | "Father of the Bride" actor who won the Mark Twain Prize for American Humor in 2005: 2 wds. |
| 68% | LENO | 4 | Jay who won the Mark Twain Prize for American Humor in 2014 |
| 68% | LENO | 4 | Jay ___, TV host who won the Mark Twain Prize for American Humor in 2014 |
| 62% | FEY | 3 | Tina who won the Mark Twain Prize for American Humor |
| 61% | RICHARDPRYOR | 12 | "Silver Streak" star who was awarded the very first Mark Twain Prize for American Humor in 1998: 2 wds. |
| 57% | DAVECHAPPELLE | 13 | "A Star Is Born" actor who won the Mark Twain Prize in 2019: 2 wds. |
| 57% | ADAMSANDLER | 11 | "Grown Ups" actor who won the Mark Twain Prize in 2023: 2 wds. |
| 54% | LORNEMICHAELS | 13 | "Saturday Night Live" creator who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 53% | CONAN | 5 | O’Brien who was awarded the Mark Twain Prize for American Humor, in 2025 |
| 53% | FEY | 3 | Tina who won the 2010 Mark Twain Prize for American Humor |
| 53% | LENO | 4 | Jay who won the 2014 Mark Twain Prize for American Humor |
| 53% | ADAM | 4 | Sandler who won the 2023 Mark Twain Prize for American Humor |
| 53% | EDDIEMURPHY | 11 | Former "Saturday Night Live" regular who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 53% | WILLFERRELL | 11 | Former "Saturday Night Live" regular who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 53% | WILLFERRELL | 11 | "Elf" actor who roasted 2025 Mark Twain Prize for American Humor honoree Conan O'Brien: 2 wds. |
| 53% | FEY | 3 | Tina who won a Mark Twain Prize for American Humor |
| 52% | LENO | 4 | TV host who won a Mark Twain Prize for American Humor |
| 47% | LENO | 4 | 2014 winner of the Mark Twain Prize for American Humor |
| 47% | FEY | 3 | 2010 recipient of the Mark Twain Prize for American Humor |
| 47% | XXXXXXXXXX | 10 | 2022 winner of the Mark Twain Prize for American Humor |
| 47% | FEY | 3 | Youngest recipient of the Mark Twain Prize for American Humor (2010) |
| 47% | ARTHURASHKIN | 12 | American scientist who won one half of the 2018 Nobel Prize in Physics for his work on optical tweezers: 2 wds. |
| 46% | LENO | 4 | Late-night host who won the Mark Twain Prize in 2014 |
| 45% | SALMANRUSHDIE | 13 | Author who won the Man Booker Prize in 1981 for "Midnight's Children": 2 wds. |
| 45% | GEORGECARLIN | 12 | "Brain Droppings" writer/comedian posthumously honored with the 2008 Mark Twain Prize for American Humor (2 wds.) |
| 45% | CARLREINER | 10 | "I Remember Me" writer/comedian honored with the 2000 Mark Twain Prize for American Humor (2 wds.) |
| 45% | BILLMURRAY | 10 | Former "Saturday Night Live" comedian honored with the 2016 Mark Twain Prize for American Humor (2 wds.) |