| 100% | SIMS | 4 | "The ___," bestselling PC game with virtual characters |
| 52% | SIMS | 4 | PC game sensation of the early 2000s, with "The" |
| 51% | RAIDER | 6 | Video game with the character Lara Croft: Tomb __ |
| 48% | SIMS | 4 | Popular game with virtual people, with "The" |
| 48% | JONSNOW | 7 | Game of Thrones character with the direwolf Ghost |
| 48% | MYST | 4 | Video game franchise with the main character Atrus |
| 48% | SIMS | 4 | "The ___" (video game with virtual citizens) |
| 46% | RICHUNCLE | 9 | With 35-Across, wealthy character from the board game Monopoly: 2 wds. |
| 45% | DONKEYKONG | 10 | Video game with a gorilla that first featured the main character of 43-Across (2 wds.) |
| 44% | PAC | 3 | ___-Man, famous arcade game character who is associated with the color at 42a |
| 44% | THESIMS | 7 | Computer game with virtual people |
| 44% | SIMS | 4 | The ___ (game with virtual people) |
| 43% | LARACROFT | 9 | Video game character with the most appearances on magazine covers, per Guinness (1,200+) |
| 43% | MARIO | 5 | First video game character to be honored with a figure in the Hollywood Wax Museum |
| 43% | HALO | 4 | Xbox game series with the A.I. character who inspired Microsoft's voice-assistant Cortana |
| 43% | HALO | 4 | Xbox game series with the A.I. character who inspired Microsoft's voice assistant Cortana |
| 42% | MYST | 4 | PC game with a VR remake released in 2020 |
| 42% | CONTRA | 6 | Run and gun video game published in 1988 by Konami with the characters Bill and Lance |
| 42% | MARIOBROS | 9 | Video game franchise with characters found at the ends of 17-, 20-, 53- and 58-Across |
| 42% | THESIMS | 7 | PC game with Livin' Large and Hot Date expansion packs |
| 41% | DUCKDUCKGOOSE | 13 | Game with taps on the head |
| 41% | SIMS | 4 | Characters in the video game designer Will Wright's "virtual dollhouse" |
| 41% | CHINESECHECKERS | 15 | Game with a star in the middle |
| 40% | MYST | 4 | Hit PC game of the 1990s |
| 40% | SIMS | 4 | Virtual video game characters |
| 40% | MYST | 4 | Popular game with the sequel Riven |
| 39% | MARIO | 5 | "The Godfather" author who shares his name with a video game character |
| 39% | HOLDEM | 6 | Game with the flop, the turn and the river |
| 39% | WAR | 3 | Game with the objective of winning all the cards |
| 39% | DND | 3 | Game with a 56-Across character class, for short |