| 100% | EDDIEMURPHY | 11 | "The Nutty Professor" actor and "SNL" star who won the Mark Twain Prize for American Humor in 2015: 2 wds. |
| 72% | LORNEMICHAELS | 13 | "SNL" producer who won the Mark Twain Prize for American Humor in 2004: 2 wds. |
| 71% | WILLFERRELL | 11 | "Elf" actor and "Saturday Night Live" star who won the Mark Twain Prize for American Humor in 2011: 2 wds. |
| 67% | STEVEMARTIN | 11 | "Father of the Bride" actor who won the Mark Twain Prize for American Humor in 2005: 2 wds. |
| 58% | LENO | 4 | Jay who won the Mark Twain Prize for American Humor in 2014 |
| 58% | LENO | 4 | Jay ___, TV host who won the Mark Twain Prize for American Humor in 2014 |
| 57% | DAVECHAPPELLE | 13 | "A Star Is Born" actor who won the Mark Twain Prize in 2019: 2 wds. |
| 56% | RICHARDPRYOR | 12 | "Silver Streak" star who was awarded the very first Mark Twain Prize for American Humor in 1998: 2 wds. |
| 53% | WILLFERRELL | 11 | "Elf" actor who roasted 2025 Mark Twain Prize for American Humor honoree Conan O'Brien: 2 wds. |
| 53% | ADAMSANDLER | 11 | "Grown Ups" actor who won the Mark Twain Prize in 2023: 2 wds. |
| 53% | FEY | 3 | Tina who won the Mark Twain Prize for American Humor |
| 51% | LORNEMICHAELS | 13 | "Saturday Night Live" creator who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 51% | EDDIEMURPHY | 11 | Former "Saturday Night Live" regular who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 51% | WILLFERRELL | 11 | Former "Saturday Night Live" regular who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 50% | CONAN | 5 | O’Brien who was awarded the Mark Twain Prize for American Humor, in 2025 |
| 47% | SYLVIAPLATH | 11 | American poet and novelist who won a posthumous Pulitzer Prize for "The Collected Poems" in 1982: 2 wds. |
| 46% | FEY | 3 | Tina who won a Mark Twain Prize for American Humor |
| 46% | LENO | 4 | TV host who won a Mark Twain Prize for American Humor |
| 46% | JEREMYSTRONG | 12 | "Succession" star who won the 2020 Emmy for Outstanding Lead Actor in a Drama Series: 2 wds. |
| 45% | EUGENELEVY | 10 | "Schitt's Creek" star who won the 2020 Emmy for Outstanding Lead Actor in a Comedy Series: 2 wds. |
| 45% | FEY | 3 | Tina who won the 2010 Mark Twain Prize for American Humor |
| 45% | LENO | 4 | Jay who won the 2014 Mark Twain Prize for American Humor |
| 45% | ADAM | 4 | Sandler who won the 2023 Mark Twain Prize for American Humor |
| 45% | CAROLBURNETT | 12 | Comedian and variety show host who was awarded the Mark Twain Prize in 2013: 2 wds. |
| 45% | ROBERTFROST | 11 | American poet behind "A Witness Tree" who won the Pulitzer Prize in 1924, 1931, 1937 and 1943: 2 wds. |
| 44% | GEORGECARLIN | 12 | "Brain Droppings" writer/comedian posthumously honored with the 2008 Mark Twain Prize for American Humor (2 wds.) |
| 44% | CARLREINER | 10 | "I Remember Me" writer/comedian honored with the 2000 Mark Twain Prize for American Humor (2 wds.) |
| 44% | BILLYCRYSTAL | 12 | "Still Foolin' 'Em" writer/comedian honored with the 2007 Mark Twain Prize for American Humor (2 wds.) |
| 44% | BILLMURRAY | 10 | Former "Saturday Night Live" comedian honored with the 2016 Mark Twain Prize for American Humor (2 wds.) |
| 44% | DAVECHAPPELLE | 13 | Former "Saturday Night Live" comedian honored with the 2019 Mark Twain Prize for American Humor (2 wds.) |