| 100% | SHERLOCK | 8 | ___ Holmes, fictional detective created by Arthur Conan Doyle |
| 92% | SHERLOCK | 8 | ___ Holmes, fictional detective created by Arthur Conan Doyle, who you may associate with 20a, 33a, 42a, 9d, and 36d |
| 89% | SHERLOCKHOLMES | 14 | Fictional detective created by Arthur Conan Doyle: 2 wds. |
| 69% | SILVERBLAZE | 11 | 1892 story by Arthur Conan Doyle featuring detective Sherlock Holmes |
| 65% | IRENEADLER | 10 | Holmes character created by Arthur Conan Doyle who may be modeled after Lillie Langtry or Lola Montez |
| 63% | IRENE | 5 | Adler created by Arthur Conan Doyle |
| 63% | IRENEADLER | 10 | Opera singer created by Arthur Conan Doyle |
| 58% | SIGNOFFOUR | 10 | The —, 1890 novel by Arthur Conan Doyle featuring Sherlock Holmes |
| 58% | LOST | 4 | "The ___ World," first book featuring the character of Professor Challenger created by Arthur Conan Doyle |
| 57% | SHERLOCK | 8 | Sir Arthur Conan Doyle's fictional detective |
| 57% | SHERLOCK | 8 | Detective in an Arthur Conan Doyle book: __ Holmes |
| 54% | LESTRADE | 8 | Fictional Scotland Yard inspector in stories by Arthur Conan Doyle involving Sherlock Holmes who first appeared in A Study in Scarlet |
| 51% | MICAH | 5 | & 21A 1889 novel by Arthur Conan Doyle |
| 51% | THEDOINGSOF | 11 | & 25A 1892 novel by Arthur Conan Doyle |
| 50% | JANEMARPLE | 10 | Fictional detective created by Agatha Christie: 2 wds. |
| 50% | PHILIPMARLOWE | 13 | Fictional detective created by Raymond Chandler: 2 wds. |
| 50% | MIKEHAMMER | 10 | Fictional detective created by Mickey Spillane: 2 wds. |
| 49% | SHERLOCK | 8 | __ Holmes, character by Sir Arthur Conan Doyle |
| 49% | LANDOFMIST | 10 | The —, 1926 novel by Arthur Conan Doyle |
| 46% | VALLEY | 6 | "The Mystery of the Sasassa ___," first published work by Arthur Conan Doyle |
| 46% | JESSESTONE | 10 | Fictional detective created by novelist 33-Across and played by actor 43-Across (2 wds.) |
| 46% | FINAL | 5 | "The ___ Problem," Sherlock Holmes short story by Arthur Conan Doyle |
| 46% | SIR | 3 | ___ Arthur Conan Doyle (title for the creator of Sherlock Holmes) |
| 45% | NERO | 4 | Fictional detective Wolfe created by Rex Stout |
| 44% | STUDY | 5 | "A ___ in Scarlet" (first Sherlock Holmes novel by Arthur Conan Doyle) |
| 44% | LOT | 3 | "___ No. 249," gothic horror short story by Arthur Conan Doyle that influenced the Mummy horror genre |
| 44% | STONE | 5 | "Rodney ___," gothic mystery novel by Arthur Conan Doyle that was adapted as "The House of Temperley" |