| 100% | SHERLOCK | 8 | BBC show based on a series of Arthur Conan Doyle books |
| 58% | JUSTIFIED | 9 | FX show based on a series of Elmore Leonard books |
| 58% | HANNIBAL | 8 | NBC show based on a series of Thomas Harris books |
| 57% | TRUEBLOOD | 9 | HBO show based on a series of Charlaine Harris books: 2 wds. |
| 57% | GAMEOFTHRONES | 13 | HBO show based on a series of George R.R. Martin books: 3 wds. |
| 52% | ELEMENTARY | 10 | CBS detective series based on the characters of Arthur Conan Doyle |
| 48% | WILL | 4 | "___ Trent" (ABC show based on a book series) |
| 42% | IRREGULARS | 10 | "The ___," 2021 period drama series based on the works of Sir Arthur Conan Doyle |
| 41% | INCOLDBLOOD | 11 | *1967 movie based on a series of New Yorker articles by Truman Capote |
| 40% | OUTLANDER | 9 | Starz show based on a Diana Gabaldon fantasy series |
| 40% | WALKING | 7 | Hit show based on a comic book, The __ Dead |
| 40% | MEETMEINSTLOUIS | 15 | *1944 movie based on a series of New Yorker short stories by Sally Benson |
| 40% | PLAZA | 5 | "Eloise at the ___" (Disney film based on a series of Kay Thompson children's novels) |
| 40% | TITANS | 6 | "Teen ___ Go!" (Cartoon Network show based on a DC Comics series) |
| 39% | WATCHMEN | 8 | 2019 HBO show based on a DC Comics series written by Alan Moore |
| 38% | DREDD | 5 | "Judge ___" (Sylvester Stallone film based on a comic book series) |
| 37% | CATS | 4 | 1982 Broadway musical based on a book of T.S. Eliot poems |
| 37% | EVERYTHING | 10 | "The Theory of ___," book by Stephen Hawking based on a series of lectures given at Cambridge University |
| 36% | GAMEOFTHRONES | 13 | Current HBO series based on a series of George R.R. Martin fantasy novels: 3 wds. |
| 35% | CLUEDO | 6 | British mystery game show based on a board game where celebrity guests had to solve the case of a reenacted murder |
| 35% | YOU | 3 | "___ Don't Know Jack," 2001 game show based on the video game series of the same name |
| 35% | MASK | 4 | "The ___," 1994 Jim Carrey movie that is based on a comic book series by Dark Horse Comics |
| 35% | SOUTH | 5 | "___ Pacific," musical based on a Pulitzer-winning book which was released during the Golden Age of Broadway |
| 35% | ANNE | 4 | "___ with an E" (show based on a Lucy Maud Montgomery book) |
| 35% | BEWITCHED | 9 | 2005 American romantic comedy film based on a TV show of the same name directed by Nora Ephron |
| 35% | NOW | 3 | "The Spectacular ___," romantic comedy film which was based on a book of the same name by Tim Tharp |
| 34% | THELOSTCITYOFZ | 14 | Charlie Hunnam film based on a 52-Across book subtitled "A Tale of Deadly Obsession in the Amazon" (5 wds.) |
| 34% | ANNIE | 5 | Broadway show based on a comic strip |
| 34% | JANETHEVIRGIN | 13 | CW show based on a Venezuelan telenovela |
| 34% | ACCUMULATOR | 11 | Bet placed on a series of events |