| 100% | MAYIMBIALIK | 11 | Actress who played young C.C. Bloom in the 1988 film "Beaches" and Amy Farrah Fowler on "The Big Bang Theory" in 2019: 2 wds. |
| 49% | WINONARYDER | 11 | Actress who played Lydia Deetz in the 1988 film "Beetlejuice" and Joyce Byers on "Stranger Things" in 2019: 2 wds. |
| 45% | MOLLYRINGWALD | 13 | Actress who played Sam Baker in the 1984 film "Sixteen Candles" and Mary Andrews on "Riverdale" in 2019: 2 wds. |
| 44% | EMMATHOMPSON | 12 | Actress who plays the protagonist in "Nanny McPhee and the Big Bang," which is based on the "Nurse Matilda" books: 2 wds. |
| 44% | MAYIM | 5 | ___ Bialik, actress who plays Amy Farrah Fowler in "The Big Bang Theory" |
| 41% | MAYIMBIALIK | 11 | She plays Dr. Amy Farrah Fowler—a neurobiologist—on CBS's "The Big Bang Theory": 2 wds. |
| 40% | HARP | 4 | Stringed instrument played by Amy Farrah Fowler on "The Big Bang Theory" |
| 38% | KALEYCUOCO | 10 | Actress who plays Penny on "The Big Bang Theory" (2 wds.) |
| 38% | JIMPARSONS | 10 | Actor who portrayed Sheldon Cooper in "The Big Bang Theory," and is the narrator in "Young Sheldon": 2 wds. |
| 37% | JIMPARSONS | 10 | "The Big Bang Theory" actor who played Michael in "The Boys in the Band": 2 wds. |
| 37% | VANESSAKIRBY | 12 | "The Crown" actress who plays Hattie Shaw in the 2019 "The Fast and the Furious" spin-off "Hobbs & Shaw": 2 wds. |
| 37% | LAURIEMETCALF | 13 | "The Conners" actress who played Sheldon's mother on "The Big Bang Theory" (2 wds.) |
| 37% | LETITIAWRIGHT | 13 | Actress who plays Shuri in the Marvel Cinematic Universe and has been on "Black Mirror": 2 wds. |
| 37% | KATEYSAGAL | 10 | "Sons of Anarchy" actress who played Penny's mother on "The Big Bang Theory" (2 wds.) |
| 37% | STEVEWOZNIAK | 12 | Co-founder of Apple and noted philanthropist who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 36% | ELONMUSK | 8 | CEO of SpaceX and product architect of Tesla who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 36% | ELIZABETHOLSEN | 14 | Actress who plays a powerful witch in Marvel's "Avengers" films and on 44-Across (2 wds.) |
| 36% | JULIEANDREWS | 12 | "The Sound of Music" actress who played the nanny Mary Poppins in the 1964 film: 2 wds. |
| 36% | ISABELSANFORD | 13 | Actress who played Louise on "All in the Family" and 45-Across (2 wds.) |
| 36% | KRISTENSTEWART | 14 | Actress who plays Norah Price in the film "Underwater" and also played the role of Bella Swan in "The Twilight" series: 2 wds. |
| 35% | AUBREYPLAZA | 11 | Actress who meets her younger self played by Maisy Stella in the 2024 film "My Old Ass": 2 wds. |
| 35% | NAVIDNEGAHBAN | 13 | Actor who appeared in "24," "Homeland" and is playing The Sultan in 2019 film "Aladdin": 2 wds. |
| 35% | VIVIENLEIGH | 11 | Actress who played Scarlett O'Hara in the film "Gone With the Wind" and also won an Oscar for her work in the film: 2 wds. |
| 35% | MAYIMBIALIK | 11 | "The Big Bang Theory" actress who earned a doctorate in neuroscience from 33-Down: 2 wds. |
| 35% | DIANEKRUGER | 11 | Actress who plays Dr. Abigail Chase in the "National Treasure" films: 2 wds. |
| 35% | LAURALINNEY | 11 | "The Big C" actress who plays Wendy Byrde on "Ozark": 2 wds. |
| 35% | FELICITYJONES | 13 | Actress who played Ruth Bader Ginsburg in the film "On the Basis of Sex": 2 wds. |
| 35% | ANGELABASSETT | 13 | Actress who played rock star Tina Turner in the 1993 film "What's Love Got to Do With It": 2 wds. |
| 35% | KRYSTENRITTER | 13 | Actress who plays the Marvel Comics hero Jessica Jones in "Jessica Jones" and "The Defenders" on Netflix (2 wds.) |
| 35% | LAURIEMETCALF | 13 | "The Big Bang Theory" actress whose daughter portrays her character's younger self on "Young Sheldon": 2 wds. |