| 100% | MAYIMBIALIK | 11 | Former "Blossom" and "The Big Bang Theory" star who co-hosts "Jeopardy!" (2 wds,) |
| 59% | BIALIK | 6 | The Big Bang Theory and Blossom star Mayim |
| 58% | CHUCKLORRE | 10 | Creator of "Two and a Half Men" and "The Big Bang Theory," who is also the co-creator of CBS's new show "Young Sheldon": 2 wds. |
| 56% | YOUNGSHELDON | 12 | "The Big Bang Theory" prequel starring 13-Across and 27-Across (2 wds.) |
| 54% | JIMPARSONS | 10 | "The Big Bang Theory" actor who played Michael in "The Boys in the Band": 2 wds. |
| 53% | JIMPARSONS | 10 | Actor who portrayed Sheldon Cooper in "The Big Bang Theory," and is the narrator in "Young Sheldon": 2 wds. |
| 53% | JAMIEFOXX | 9 | "Django Unchained" star who hosted the ESPY Awards in 2003 and 2004: 2 wds. |
| 52% | ARIANAGRANDE | 12 | Pop singer and former Nickelodeon star who both hosted "SNL" and performed as the musical guest in 2016: 2 wds. |
| 51% | JIMPARSONS | 10 | Star of "The Big Bang Theory": 2 wds. |
| 51% | MAYIMBIALIK | 11 | "The Big Bang Theory" actress who earned a doctorate in neuroscience from 33-Down: 2 wds. |
| 50% | STEVEWOZNIAK | 12 | Co-founder of Apple and noted philanthropist who did a guest appearance on "The Big Bang Theory": 2 wds. |
| 49% | JIMPARSONS | 10 | "The Big Bang Theory" actor who narrates 44-Across (2 wds.) |
| 49% | SHELDONCOOPER | 13 | "The Big Bang Theory" character with the catchphrase "Bazinga!": 2 wds. |
| 48% | ROSEANNEBARR | 12 | Former sitcom star who ran for president in 2012 on the Peace and Freedom Party ticket: 2 wds. |
| 47% | MAYIMBIALIK | 11 | "Call Me Kat" star who hosted "Jeopardy!" for two weeks in May and June: 2 wds. |
| 47% | MAYIM | 5 | "The Big Bang Theory" actress __ Bialik who is also a scheduled 2021 "Jeopardy!" guest host |
| 47% | RUSSELLWILSON | 13 | Former Seattle Seahawks quarterback who co-hosted the 2020 ESPY Awards with Megan Rapinoe and Sue Bird (2 wds.) |
| 47% | DONALDGLOVER | 12 | Rapper and "Atlanta" star who both hosted "SNL" and performed as the musical guest in 2018: 2 wds. |
| 47% | JIMPARSONS | 10 | "The Big Bang Theory" actor who was nominated for an Emmy Award for "Hollywood" (2 wds.) |
| 46% | WIL | 3 | Wheaton who starred in The Big Bang Theory |
| 45% | LORRE | 5 | "The Big Bang Theory" and "Young Sheldon" co-creator Chuck |
| 45% | JAMESCORDEN | 11 | Late-night star who hosted the 2016 Tony Awards: 2 wds. |
| 45% | KALEYCUOCO | 10 | "The Big Bang Theory" actress who says "Every trip is a big deal" in Priceline.com commercials (2 wds.) |
| 45% | DANICAPATRICK | 13 | Former NASCAR/IndyCar racing star who hosted the 2018 ESPY Awards ceremony (2 wds.) |
| 45% | MARIAHCAREY | 11 | Pop star who performed and cowrote the song at 19-/33-Across: 2 wds. |
| 45% | LESLIEJONES | 11 | "Saturday Night Live" star who hosted the 2017 BET Awards: 2 wds. |
| 45% | BURTREYNOLDS | 12 | "Smokey and the Bandit" star who died 9/6/18: 2 wds. |
| 45% | LORRE | 5 | Chuck who co-created "The Big Bang Theory" and "Two and a Half Men" |
| 45% | LINA | 4 | Chinese tennis star who has won the French and Australian Opens: 2 wds. |
| 44% | JULIANNEHOUGH | 13 | Former dancer and judge on "Dancing With the Stars": 2 wds. |