| 100% | SOUTHPARK | 9 | Animated Comedy Central series set in a small town in Colorado: 2 wds. |
| 57% | SOUTHPARK | 9 | Animated series starring Trey Parker and Matt Stone that's named for a fictional town in Colorado: 2 wds. |
| 56% | SOUTHPARK | 9 | Animated comedy series set in a Colorado town |
| 49% | SCHITTSCREEK | 12 | Comedy series starring Eugene Levy that's named for a fictional town in Canada: 2 wds. |
| 48% | SOUTHPARK | 9 | Comedy Central animated series that wrapped its 25th season in 2022: 2 wds. |
| 46% | ADVENTURETIME | 13 | Animated Cartoon Network series set in the Land of Ooo: 2 wds. |
| 45% | VIRGINRIVER | 11 | Romance series by Robyn Carr set in a California mountain town (2 wds.) |
| 45% | FAMILYGUY | 9 | Animated Fox series set in Quahog, Rhode Island: 2 wds. |
| 44% | ORANGEIS | 8 | With 33- and 52-Across, television series set in a women's prison: 2 wds. |
| 43% | THEGOLDBERGS | 12 | ABC comedy series set in the 1980s: 2 wds. |
| 43% | SOUTHPARK | 9 | Animated series on Comedy Central: 2 wds. |
| 42% | YOGIBEAR | 8 | "The ___ Show," animated series set in Jellystone Park: 2 wds. |
| 42% | SOUTHPARK | 9 | Long-running animated series set in the Rockies: 2 wds. |
| 42% | NURSEJACKIE | 11 | Showtime comedy-drama set in a hospital that ended this summer: 2 wds. |
| 42% | TWINPEAKS | 9 | Mystery series starring Kyle MacLachlan that's named for a fictional town in Washington: 2 wds. |
| 41% | FAMILYGUY | 9 | Animated series in which Mila Kunis voices a daughter named Meg: 2 wds. |
| 41% | JUDDHIRSCH | 10 | 1981 Emmy winner for "Taxi" (Outstanding Lead Actor In a Comedy Series): 2 wds. |
| 41% | OZARK | 5 | Netflix crime drama set in a small town in Missouri |
| 40% | AMERICANRUST | 12 | Novel by 31-Across set in a declining Pennsylvania steel town (2 wds.) |
| 40% | MAINST | 6 | Sign in the heart of many a small town's downtown (2 wds.) |
| 40% | MAIN | 4 | "___ Street" (Sinclair Lewis novel set in a small town in Minnesota) |
| 39% | STRANGERTHINGS | 14 | Netflix series set in the 1980s in which single mom Joyce Byers contends with a supernatural monster: 2 wds. |
| 39% | KAWHILEONARD | 12 | Raptors small forward who made a series-ending buzzer beater against the 76ers in 2019: 2 wds. |
| 39% | ERICMCCORMACK | 13 | 2001 Emmy winner, Outstanding Lead Actor in a Comedy Series (for "Will & Grace"): 2 wds. |
| 39% | GRACEVALLEY | 11 | Romance trilogy by Robyn Carr set in a California mountain town (2 wds.) |
| 39% | STATE | 5 | "___ and Main" (William H. Macy film set in a small town) |
| 39% | MAIN | 4 | "State and ___" (William H. Macy film set in a small town) |
| 39% | UNCLEBUCK | 9 | John Candy family comedy set in a Chicago suburb (2 wds.) |
| 39% | RISKYBUSINESS | 13 | Tom Cruise teen comedy set in a Chicago suburb (2 wds.) |
| 39% | HOMEALONE | 9 | Macaulay Culkin Christmas comedy set in a Chicago suburb (2 wds.) |