| 100% | FAMILYGUY | 9 | Animated TV series featuring the voices of Seth MacFarlane and 43-Across (2 wds.) |
| 68% | FAMILYGUY | 9 | Seth MacFarlane animated series featuring the voices of 15-Across, 26-Across, and 34-Across that debuted in 1999 (2 wds.) |
| 53% | CARMENSANDIEGO | 14 | Netflix animated adventure series featuring the voice of 49-Across as the title character (2 wds.) |
| 49% | WRECKITRALPH | 12 | 2012 animated film featuring the voices of John C. Reilly and Sarah Silverman: 2 wds. |
| 48% | IAMNOTAN | 8 | & 6D 2004 BBC TV animated comedy series featuring the voice talent of Steve Coogan and Amelia Bullmore |
| 45% | THECROODS | 9 | 2013 animated film set in the Pliocene Era featuring the voice of 43-Across (2 wds.) |
| 44% | THEXFILES | 9 | Paranormal TV series featuring the characters 15-Across, 21-Across, and 41-Across that debuted in 1993 (2 wds.) |
| 44% | ICEAGE | 6 | Animated film franchise featuring the voice of Ray Romano (2 wds.) |
| 43% | TRES | 4 | "Maya y los ___" (animated Netflix series featuring the voices of Zoe Saldaña and Rita Moreno) |
| 43% | MELBLANC | 8 | The voice of 15-Across and many other Looney Tunes characters: 2 wds. |
| 41% | GOSSIPGIRL | 10 | TV series with Blake Lively and Leighton Meester that is based on Cecily von Ziegesar's novel of the same name: 2 wds. |
| 41% | KUNGFU | 6 | "___ Panda," 2008 animated movie featuring the voice of Jack Black: 2 wds. |
| 40% | ASTROBOY | 8 | Manga-based animated film featuring the voice of 28-Across as a robot named Mr. Squeegee (2 wds.) |
| 40% | HARLEYQUINN | 11 | HBO Max animated series, about the Joker's ex-girlfriend, that features the voice of Alan Tudyk: 2 wds. |
| 39% | ANTZ | 4 | Animated film featuring the voices of Gene Hackman and Sylvester Stallone |
| 39% | THEORVILLE | 10 | Sci-fi TV series created by and starring Seth MacFarlane as Captain Ed Mercer (2 wds.) |
| 39% | FAMILY | 6 | "___ Guy," animated TV series that features Queen's album "News of the World" |
| 38% | THEATEAM | 8 | TV show featuring the characters Hannibal and Face: 2 wds., hyph. |
| 38% | ROGUEONE | 8 | "Star Wars" prequel film featuring the voice of 28-Across as a droid named K-2SO (2 wds.) |
| 38% | DIVINEJUSTICE | 13 | Fourth novel in a series featuring Oliver Stone and his group of political watchdogs called the Camel Club (2 wds.) |
| 38% | KRISTENBELL | 11 | The voice of Princess Anna in 32-Across: 2 wds. |
| 37% | MONSTERSINC | 11 | Animated film featuring 42-Across as the voice of a green, one-eyed scarer assistant named Mike Wazowski (2 wds.) |
| 37% | LENAWAITHE | 10 | Creator/writer of the TV series "The Chi" and "Boomerang" (2 wds.) |
| 37% | IDINAMENZEL | 11 | The voice of Elsa the Snow Queen in 32-Across: 2 wds. |
| 36% | BOBSBURGERS | 11 | Fox animated sitcom that once featured the voice of "Mad Men" star Jon Hamm as a toilet (2 wds.) |
| 36% | LOKI | 4 | TV series featuring the Norse god of mischief |
| 36% | SHONDARHIMES | 12 | Creator/writer of the TV series "Grey's Anatomy" and "Scandal" (2 wds.) |
| 36% | AMERICANDAD | 11 | Animated show in which the father (voiced by Seth MacFarlane) works for the CIA: 2 wds. |
| 36% | MODOK | 5 | 2021 animated series based on a Marvel Comics character and featuring the voices of Aimee Garcia and Ben Schwartz |