| 100% | MORIARTY | 8 | Arch-enemy of Sherlock Holmes |
| 80% | MORIARTY | 8 | Professor James —, arch-enemy of Sherlock Holmes in stories by Arthur Conan Doyle |
| 71% | MYCROFT | 7 | Elder brother of Sherlock Holmes |
| 68% | ASTUDYINSCARLET | 15 | Debut of Sherlock Holmes |
| 68% | DOYLE | 5 | Creator of Sherlock Holmes |
| 68% | MYCROFT | 7 | Brother of Sherlock Holmes |
| 67% | IRENE | 5 | Adler of Sherlock Holmes stories |
| 67% | ACD | 3 | Monogram of Sherlock Holmes' creator |
| 67% | IRENE | 5 | Adler of Sherlock Holmes fame |
| 66% | DEERSTALKER | 11 | Part of Sherlock Holmes's attire |
| 66% | DOYLE | 5 | Arthur Conan ___ (creator of Sherlock Holmes) |
| 66% | ARTHUR | 6 | ___ Conan Doyle, creator of Sherlock Holmes |
| 66% | SCOTLAND | 8 | __ Yard, workplace of Sherlock Holmes' Lestrade |
| 64% | BRETT | 5 | Jeremy ___, 1980s-'90s portrayer of Sherlock Holmes |
| 64% | INSPECTOR | 9 | Lestrade of Sherlock Holmes stories, e.g. |
| 64% | ARTHUR | 6 | Sir __ Conan Doyle, writer of Sherlock Holmes |
| 64% | DOYLE | 5 | Sir Arthur Conan ___, creator of Sherlock Holmes |
| 63% | ADLER | 5 | Irene who's a frenemy of Sherlock Holmes |
| 62% | NATE | 4 | With 20-Down, kiddie-lit counterpart of Sherlock Holmes |
| 62% | BASIL | 5 | First name of Sherlock Holmes actor from the 1940s |
| 62% | MORIARTY | 8 | Sherlock Holmes' adversary, the Napoleon of Crime |
| 61% | SIR | 3 | ___ Arthur Conan Doyle (title for the creator of Sherlock Holmes) |
| 61% | MING | 4 | ___ the Merciless, arch enemy of the comic superhero Flash Gordon |
| 60% | CLIVE | 5 | ___ Merrison, actor known for his BBC Radio portrayal of Sherlock Holmes |
| 59% | NIGEL | 5 | Actor Bruce who played Watson in "The New Adventures of Sherlock Holmes" |
| 59% | MORIARTY | 8 | Professor James —, archenemy of Sherlock Holmes in tales by Arthur Conan Doyle |
| 58% | ENOLA | 5 | Sherlock Holmes's younger sister in a series of YA novels |
| 56% | BELL | 4 | Joseph ___, surgeon whom Arthur Conan Doyle cites as inspiration for the character of Sherlock Holmes |
| 54% | BRETT | 5 | Jeremy —, actor who played the title role in 1980s ITV drama series The Adventures of Sherlock Holmes |
| 54% | ZUCCO | 5 | George —, Manchester-born actor who played Professor Moriarty in 1939 film drama The Adventures of Sherlock Holmes |