| 100% | MORIARTY | 8 | Fictional professor in Sherlock Holmes stories |
| 64% | ULSTERS | 7 | Overcoats worn in Sherlock Holmes stories |
| 63% | IRENE | 5 | ___ Adler (woman in Sherlock Holmes stories) |
| 63% | ADLER | 5 | Irene ___, figure in Sherlock Holmes stories |
| 62% | IRENE | 5 | Woman in Sherlock Holmes stories |
| 62% | IRENE | 5 | Adler in Sherlock Holmes stories |
| 60% | WATSON | 6 | Usual narrator in Sherlock Holmes stories: Dr. __ |
| 60% | INSP | 4 | Lestrade's rank, in Sherlock Holmes stories: Abbr. |
| 59% | DOGCART | 7 | Horse-drawn vehicle often mentioned in Sherlock Holmes stories |
| 55% | IRENE | 5 | Adler of the Sherlock Holmes story “A Scandal in Bohemia” |
| 55% | IRENEADLER | 10 | Woman in a Sherlock Holmes story |
| 50% | MORIARTY | 8 | Professor James —, arch-enemy of Sherlock Holmes in stories by Arthur Conan Doyle |
| 49% | FINAL | 5 | & 16A The —, Sherlock Holmes story by Arthur Conan Doyle first published in the Strand Magazine in December 1893 |
| 48% | ADLER | 5 | Irene of a Sherlock Holmes story |
| 48% | IRENEADLER | 10 | Fictional opera singer/actress who outsmarts Sherlock Holmes in the Arthur Conan Doyle story "A Scandal in Bohemia" (2 wds.) |
| 47% | BAKERSTREET | 11 | & 1A Group of street urchins who aid Sherlock Holmes in various stories by Arthur Conan Doyle |
| 47% | BEECHES | 7 | Sherlock Holmes story "The Copper ___" |
| 46% | HIS | 3 | "___ Last Bow" (1917 Sherlock Holmes story) |
| 46% | IRENE | 5 | Adler of Sherlock Holmes stories |
| 46% | IRENE | 5 | ___ Adler from Sherlock Holmes stories |
| 45% | IRENE | 5 | Adler in Sherlock Holmes fiction |
| 44% | PASTICHE | 8 | Sherlock Holmes story not by Conan Doyle, e.g. |
| 44% | INSPECTOR | 9 | Lestrade of Sherlock Holmes stories, e.g. |
| 44% | THELIONSMANE | 12 | Sherlock Holmes adventure, in brief |
| 43% | NIGEL | 5 | Bruce who played Watson in Sherlock Holmes films |
| 43% | BASILRATHBONE | 13 | Sherlock Holmes portrayer in 14 movies |
| 43% | BASILRATHBONE | 13 | Sherlock Holmes portrayer in 15 movies |
| 42% | BASILRATHBONE | 13 | Sherlock Holmes in "The Woman in Green" |
| 41% | JOE | 3 | ___ Deebs, fictional detective in old German films who was based on Sherlock Holmes |
| 41% | OPIUMDEN | 8 | *Setting in Sherlock Holmes's "The Man with the Twisted Lip" |