| 100% | GALILEO | 7 | Astronomer who was the first to discover that the Milky Way was made up of stars |
| 48% | MARIA | 5 | ___ Mitchell, astronomer who was the first female professor of astronomy and the first American to discover a comet |
| 45% | BESSEL | 6 | German astronomer who was the first to measure the distance to a star |
| 38% | HILLARYCLINTON | 14 | Secretary of State who was the first to visit Burma since 1955 |
| 38% | MOUNTAINCLIMBER | 15 | One who encounters the last parts of the answers to the starred clues on the way up |
| 38% | WATER | 5 | "Avatar: The Way of ___," 2022 film starring Zoe Saldana that is a sequel to a 2009 film |
| 38% | SIDNEYPOITIER | 13 | 15-Across, 30-Across, and "Lilies of the Field" star who was the first Black man to win an Academy Award for Best Actor (2 wds.) |
| 37% | HAYES | 5 | Actress Helen who was the first person to win the Triple Crown of Acting |
| 37% | OURGANG | 7 | Old group of movie kids that, in a way, the answers to starred clues could be a member of |
| 37% | STEVENASH | 9 | Basketball Hall of Famer who was the first Canadian to win the NBA MVP award |
| 37% | CLINE | 5 | Patsy ___, "Walkin' After Midnight" singer who was one of the first country stars to cross over to pop music charts |
| 37% | DOROTHYARZNER | 13 | “The Bride Wore Red” director who was the first woman to join the Directors Guild of America |
| 37% | XXXXXXXX | 8 | Like a poker player who keeps getting everyone to fold before the first bet is made? |
| 37% | PATSY | 5 | Cline who was the first solo female artist elected to the Country Music Hall of Fame |
| 37% | MARSAIMARTIN | 12 | Producer who was the first cover star of Essence's Girls United |
| 36% | OLGA | 4 | Korbut who was the first inductee to the International Gymnastics Hall of Fame |
| 36% | SCOTT | 5 | Michael ___, entrepreneur who was the first CEO of Apple from 1977 to 1981 |
| 36% | POTATOHEAD | 10 | Toy that can be either Mr. or Mrs. ... and what the first part of the answers to starred clues can literally be |
| 36% | STTERESA | 8 | First woman to be made doctor of the Roman Catholic Church |
| 36% | PEARSON | 7 | Surname of the singers who made up Five Star |
| 36% | BARBARA | 7 | ___ A. Williams, American radio astronomer who was the first African-American woman to gain a PhD in Astronomy |
| 36% | ADA | 3 | Limón who is the first Latina to be Poet Laureate of the United States |
| 36% | JENNADEWAN | 10 | "Step Up" actress who was the first host of "World of Dance": 2 wds. |
| 36% | NAOMAMPBELL | 11 | *Woman who was the first Black model to appear on the cover of Time |
| 36% | SHAKESPEARE | 11 | Whom the first use of the nine long adjectives is credited to |
| 36% | ELS | 3 | Television is made up of thousands of pix___ that come together to form a picture |
| 36% | CANDICEBERGEN | 13 | "Murphy Brown" star who was the first female host of "Saturday Night Live": 2 wds. |
| 36% | VIOLA | 5 | Actress Davis who was the first African American to win the Triple Crown of Acting |
| 36% | MYSPACE | 7 | Social networking giant of the '00s that was the first to reach a global audience |
| 36% | ALTHEA | 6 | Gibson who was the first person of color to win a tennis Grand Slam event |