| 100% | MURRAY | 6 | Bill ___, "Kingpin" actor and comedian who was the first guest on the "Late Show with David Letterman" in 1993 |
| 57% | JOEL | 4 | Billy ___, "Uptown Girl" singer who was the first musical act on the "Late Show with David Letterman" in 1993 |
| 51% | REGIS | 5 | ___ Philbin, TV presenter and host who was the most frequent guest on the "Late Show with David Letterman" with 150 appearances |
| 45% | HANNA | 5 | Jack ___, zookeeper who was the second-most frequent guest on the "Late Show with David Letterman" with 103 appearances |
| 43% | COLBERT | 7 | Stephen ___, comedian who was the successor to David Letterman on the "Late Show" |
| 41% | JOANRIVERS | 10 | Comedian who was the first woman to host a late-night talk show on a major network: 2 wds. |
| 41% | JOAN | 4 | ___ Rivers, comedian and actress who was the first woman to host a late-night network TV talk show |
| 40% | DARLENE | 7 | ___ Love, singer who annually performed the song "Christmas (Baby Please Come Home)" on the "Late Show with David Letterman" |
| 37% | LEA | 3 | ___ DeLaria who became the first openly gay comic on a late-night talk show on "The Arsenio Hall Show" in 1993 |
| 36% | MILEY | 5 | With 32-Across, "Party in the U.S.A." singer who was both the host and musical guest on 2013 and 2015 "SNL" episodes |
| 36% | MANDYPATINKIN | 13 | Tony- and Emmy-winning actor who was a guest on the "On Broadway" episode of "Finding Your Roots" in 2021 (2 wds.) |
| 36% | WOLESOYINKA | 11 | Nigerian playwright and novelist who was the first African honored with the Nobel Prize in Literature (2 wds.) |
| 36% | LARRY | 5 | ___ David, comedian and actor who was the co-creator of "Seinfeld" |
| 35% | ETHELWATERS | 11 | Harlem Renaissance singer and actress who was the first African American to star in her own TV show: 2 wds. |
| 34% | DYE | 3 | Comedian Jeff ___, who was the "sidekick" to Shatner, Bradshaw, Foreman and Winkler in "Better Late Than Never " |
| 34% | WHOOPIGOLDBERG | 14 | Actress and comedian who was the first woman awarded the 44-Across (2001) (2 wds.) |
| 34% | SELMALAGERLOF | 13 | Swedish novelist and short story writer who was the first woman honored with the Nobel Prize in Literature (2 wds.) |
| 34% | SINCLAIRLEWIS | 13 | Minnesota novelist and short story writer who was the first American honored with the Nobel Prize in Literature (2 wds.) |
| 34% | HAMEL | 5 | Actress Veronica who was the model in the last cigarette ad shown on U.S. TV |
| 34% | IGGYAZALEA | 10 | "Fancy" singer featured on "Problem" who in 2014 became the second ever to be simultaneously #1 and #2 with her first two hits: 2 wds. |
| 34% | NORMMACDONALD | 13 | "SNL" actor and comedian who won $500,000 for charity on "Who Wants to Be a Millionaire" in 2000: 2 wds. |
| 33% | CAROLBURNETT | 12 | Comedian and variety show host who was awarded the Mark Twain Prize in 2013: 2 wds. |
| 33% | GRIER | 5 | David Alan ___ ("In Living Color" cast member who was on "Dancing With the Stars" in 2009) |
| 33% | CHAR | 4 | Actor who played a character with the same first name on "Two and a Half Men" |
| 33% | BATISTE | 7 | Musician Jon who led the house band on "The Late Show with Stephen Colbert" until 2022 |
| 33% | WARREN | 6 | With 35-Across, actor who played Clyde, one of the title characters on the run in 1967's "Bonnie and Clyde" |
| 33% | FRANKIEMUNIZ | 12 | "Malcolm in the Middle" actor who was a finalist on season 25 of "Dancing with the Stars" (2 wds.) |
| 33% | HAMEL | 5 | Actress Veronica who was the model in the last cigarette ad ever shown on U.S. TV (Dec. 31, 1970) |
| 33% | GARRETTMORRIS | 13 | "2 Broke Girls" actor who was honored with a star on the Hollywood Walk of Fame in 2023 (2 wds.) |
| 33% | ESSEX | 5 | David —, singer and actor who starred as Jim MacLaine in 1973 film drama That’ll Be the Day |