| 100% | MURRAY | 6 | Lexicographer James who was the O.E.D.'s first editor |
| 51% | MURRAY | 6 | James who edited the O.E.D. |
| 47% | SEAN | 4 | Actor Connery who was the first James Bond |
| 44% | EARP | 4 | James, who was not present at the O.K. Corral |
| 44% | PAUL | 4 | Beatle who was born with the first name James |
| 43% | BUCK | 4 | O'Neil who was the first African American coach in the MLB |
| 43% | BARRY | 5 | ___ Nelson, American actor who was the first to portray James Bond in a television series titled "Climax!" |
| 41% | RENO | 4 | Janet who was the U.S.’s first female Attorney General |
| 41% | REGIS | 5 | Philbin who was the first host of "America's Got Talent" |
| 41% | STU | 3 | Rasmussen who was the first openly transgender mayor in the U.S. |
| 41% | MARSAIMARTIN | 12 | Producer who was the first cover star of Essence's Girls United |
| 41% | OREE | 4 | Willie who was the N.H.L.’s first Black player |
| 40% | ULRIC | 5 | German prelate who was the first person to be canonized, A.D. 993 |
| 40% | RIC | 3 | Flair who was the first wrestler to complete the WCW's Triple Crown |
| 40% | RENO | 4 | Janet who was the first woman to serve as U.S. attorney general |
| 40% | MEL | 3 | Gibson who was the first person ever named People's Sexiest Man Alive |
| 40% | MEANY | 5 | George who was the first president of the A.F.L.-C.I.O. |
| 40% | JOHNDILLINGER | 13 | Depression-era gangster who was the FBI's first "Public Enemy #1": 2 wds. |
| 40% | ANNE | 4 | Bradstreet who was the first published writer from England's North American colonies (1650) |
| 40% | STEVEN | 6 | Yeun who was the first Asian American nominated for Best Actor (2020's "Minari") |
| 39% | ARNESS | 6 | James who starred in 1970s TV's "How the West Was Won" |
| 39% | WALLIS | 6 | Simpson who was Time's first Woman of the Year |
| 39% | DOLE | 4 | James who was known as the Pineapple King |
| 39% | SARAZEN | 7 | Gene who was the first man to win all four of golf’s modern majors |
| 39% | GIA | 3 | ___ Carangi, American model who was considered the world's first supermodel |
| 39% | BROWN | 5 | James who was Live at the Apollo in 1963 |
| 39% | DOLLY | 5 | Sheep who was the first cloned mammal |
| 39% | MEANY | 5 | Labor leader George who was the first president of the A.F.L.-C.I.O. |
| 39% | RYANZIMMERMAN | 13 | Washington Nationals infielder who was the team's first ever draft pick in 2005 (2 wds.) |
| 38% | CHRISTY | 7 | Mathewson who was in the Baseball Hall of Fame's first class |