| 100% | GENRES | 6 | Blues and rock, for two |
| 62% | CLAPTON | 7 | British rock and blues artist who sang for Layla |
| 57% | FADS | 4 | Hula Hoop and Pet Rock, for two |
| 57% | IBMS | 4 | Watson and Deep Blue, for two |
| 55% | TENSES | 6 | Past and present for two |
| 55% | WHALE | 5 | Blue and Killer, for example |
| 55% | PAULMCCARTNEY | 13 | Two-time Rock and Roll Hall of Fame inductee, with the Beatles and for his solo career: 2 wds. |
| 55% | NEILYOUNG | 9 | Two-time Rock and Roll Hall of Fame inductee, with Buffalo Springfield and for his solo career: 2 wds. |
| 54% | FORMATS | 7 | Modern rock and news/talk, for two |
| 53% | TRIOS | 5 | Rock's Cream and ZZ Top, for two |
| 52% | ETTA | 4 | James in both the Blues and Rock & Roll Halls of Fame |
| 51% | BARTOK | 6 | "Sonata for Two Pianos and Percussion" composer |
| 51% | FACTORS | 7 | Two and one, for two |
| 51% | ETTA | 4 | James in both the Blues and Rock and Roll Halls of Fame |
| 51% | MEAN | 4 | Two, for one and three? |
| 51% | SHELLEY | 7 | With 37-Across, she won two Best Supporting Actress Oscars, for "The Diary of Anne Frank" and "A Patch of Blue" |
| 49% | STL | 3 | Home of the Blues and the Cardinals, for short |
| 49% | ALECBALDWIN | 11 | Two-time Emmy winner for "30 Rock" |
| 49% | INCUBUS | 7 | Rock band known for Drive and Stellar |
| 49% | STYX | 4 | Rock band known for "Babe" and "Lady" |
| 49% | MUSIC | 5 | Rhythm and blues, for example |
| 49% | DYES | 4 | Blue rinse and henna rinse, for example |
| 49% | ICONS | 5 | Blue W for Microsoft Word and others |
| 49% | DIPS | 4 | Hummus and queso, for two |
| 49% | ARTS | 4 | Dance and drama, for two |
| 49% | ALS | 3 | Roker and Pacino, for two |
| 49% | AGENTS | 6 | Scully and Mulder, for two |
| 49% | BEAMS | 5 | Joist and transom, for two |
| 49% | EDSELS | 6 | Corsair and Citation, for two |
| 49% | EXILES | 6 | Napoleon and Amin, for two |