| 100% | GENRES | 6 | Sci-fi and mystery |
| 94% | GENRES | 6 | Sci-fi and mystery, for two |
| 72% | GENRES | 6 | Sci-fi and western |
| 65% | BENBOVA | 7 | Sci-fi author of "Venus" and "Mars" |
| 65% | COMICCON | 8 | *Mecca for sci-fi and superhero fans |
| 65% | CGI | 3 | FX in much sci-fi and fantasy |
| 65% | GENRE | 5 | Mystery or sci-fi |
| 64% | HUGOS | 5 | Awards given to sci-fi and fantasy works |
| 64% | FARSCAPE | 8 | Sci-fi series featuring John Crichton and Scorpius |
| 64% | THEXFILES | 9 | Sci-fi series about agents Mulder and Scully |
| 64% | FUTURAMA | 8 | Sci-fi show with Fry, Leela, and Bender |
| 64% | MEGACON | 7 | Annual mecca for sci-fi and fantasy fans |
| 64% | RAYS | 4 | Sci-fi author Bradbury and iconic musician Charles |
| 64% | SOURCECODE | 10 | 2011 Jake Gyllenhaal sci-fi mystery |
| 62% | STARWARS | 8 | Sci-fi series with droids and lightsabers: 2 wds. |
| 62% | NEO | 3 | Sci-fi hero whose colleagues include Morpheus and Trinity |
| 62% | ELYSIUM | 7 | Sci-fi thriller starring Matt Damon and 28-Across |
| 62% | EWOKS | 5 | Sci-fi's Chief Chirpa and Wicket W. Warrick |
| 61% | SATURNAWARDS | 12 | Annual prizes given to top sci-fi and horror films |
| 61% | SULU | 4 | Sci-fi role played by George Takei and John Cho |
| 61% | LEIA | 4 | Sci-fi princess and general with the last name Organa |
| 61% | DUNE | 4 | Sci-fi novel made into films in 1984 and 2021 |
| 61% | TIMETRAVELING | 13 | Sci-fi trope, and a hint to the circled letters |
| 60% | HAN | 3 | Sci-fi pilot Solo played by Harrison Ford and Alden Ehrenreich |
| 60% | C3PO | 4 | Sci-fi sidekick ... or a hint to 42- and 53-Across |
| 60% | R2D2 | 4 | Sci-fi sidekick ... or a hint to 20- and 34-Across |
| 59% | DUNE | 4 | 2021 sci-fi movie starring Timothée Chalamet and Zendaya |
| 58% | DOOM | 4 | Sci-fi video game that spawned several sequels and a 2005 film |
| 58% | STARWARS | 8 | Sci-fi film franchise featuring Han Solo and Princess Leia (2 wds.) |
| 58% | TOR | 3 | Sci-fi publisher of "Ender's Game" and "The Wheel of Time" |