| 100% | DISEASE | 7 | Centers for __ Control and Prevention |
| 94% | DISEASE | 7 | Centers for ___ Control and Prevention (public health agency) |
| 69% | MEDULLA | 7 | Control center for the heart and lungs |
| 53% | AMES | 4 | Mission center for IRIS and SOFIA |
| 52% | EMORY | 5 | University next to the Centers for Disease Control headquarters |
| 49% | AMFAR | 5 | Org. for H.I.V. prevention and study |
| 49% | JONATHANTOEWS | 13 | Center and captain for 38-Across since 2007 (2 wds.) |
| 48% | DAMPPROOF | 9 | Moisture control for a building's walls and floors |
| 48% | ARENAS | 6 | The United Center and Madison Square Garden, for example |
| 48% | CARAMEL | 7 | Melted butter, sugar and milk for a soft center |
| 47% | OCD | 3 | Condition treated with exposure and response prevention therapy, for short |
| 46% | SYLVIAFOWLES | 12 | Center for the Minnesota Lynx who was the WNBA Finals MVP in 2015 and 2017 (2 wds.) |
| 46% | ARENAS | 6 | SF's Chase Center and Milwaukee's Fiserv Forum, for two |
| 45% | LAURA | 5 | Singer Branigan known for "Gloria" and "Self Control" |
| 45% | CALF | 4 | Center of a Venn diagram for "Baby animals" and "Parts of the human body" |
| 44% | REC | 3 | ___ center (facility for fun and games) |
| 44% | GABBYGIFFORDS | 13 | Gun control advocate and former congresswoman for whom a naval ship is named |
| 44% | YAOMING | 7 | N.B.A. center who has pitched for McDonald's, Pepsi and Visa |
| 43% | CRANE | 5 | Center of a Venn diagram for "Birds" and "Construction equipment" |
| 43% | BREAKERPANEL | 12 | Electrical control center with switches and fuses |
| 43% | ELIE | 4 | Nobelist before Oscar and after the International Physicians for the Prevention of Nuclear War |
| 43% | EPI | 3 | Prefix for "center" and "gram" |
| 43% | TEE | 3 | Center for sportsmen |
| 43% | HOLLYWOOD | 9 | Center for cinema |
| 42% | DEP | 3 | According to their website this is "developed for active lifestyles" and will deliver "effortless control" |
| 42% | SUN | 3 | *Star at the center of our solar system, and a bright name for a newspaper |
| 42% | MAGNETSCHOOLS | 13 | Centers for drawing classes |
| 42% | POS | 3 | Centers for mail: Abbr. |
| 42% | WARROOM | 7 | Center for strategic planning |
| 42% | ONINE | 5 | Center for cat-tails? |