| 100% | SIMS | 4 | Characters in the video game designer Will Wright's "virtual dollhouse" |
| 47% | MARIO | 5 | First video game character to be honored with a figure in the Hollywood Wax Museum |
| 44% | KRISTENBELL | 11 | "The Good Place" actress who voices characters in the video games "Assassin's Creed" and "Disney Infinity" (2 wds.) |
| 44% | ALISONBRIE | 10 | "Community" actress who voices characters in the video games "Lego Dimensions" and "Marvel Avengers Academy" (2 wds.) |
| 44% | LUIGI | 5 | Plumber character who is Mario's twin brother and sidekick in the video game franchise |
| 44% | IDINAMENZEL | 11 | "Wicked" Tony winner who voices characters in the video games "Kingdom Hearts III" and "Disney Infinity" (2 wds.) |
| 44% | SIM | 3 | Video game character in a virtual city |
| 43% | ALIEN | 5 | Many a character in the "Star Control" video game series |
| 43% | SONIC | 5 | First video game character to have a balloon in the Macy's Thanksgiving Day Parade |
| 43% | ANGRYBIRDS | 10 | Video game franchise in which the enemies are pigs |
| 42% | MARIO | 5 | Main character in the best-selling video game franchise of all time |
| 41% | SATOSHITAJIRI | 13 | Japanese video game designer who is the creator of the Pokemon franchise: 2 wds. |
| 41% | MARIO | 5 | Video game character repeatedly told "but our princess is in another castle!" |
| 41% | PORTAL | 6 | Puzzle video game in which the cake is a lie |
| 41% | LUIGI | 5 | Mario's brother, in the video game |
| 40% | LAIR | 4 | Dragon's ___, '80s video game with a knight as the protagonist that is seen in "Stranger Things" |
| 40% | MARIO | 5 | Luigi's older brother, in the video games |
| 39% | AISHATYLER | 10 | "Whose Line Is It Anyway?" host who voices characters in the video games "Halo: Reach," "Gears of War 3," and "Watch Dogs" (2 wds.) |
| 38% | ORE | 3 | Mineral resource in the video game Minecraft |
| 38% | APE | 3 | Beast in the video game Donkey Kong |
| 38% | APE | 3 | Animal in the video game Donkey Kong |
| 38% | IDA | 3 | Princess in the video game "Monument Valley" |
| 38% | IDA | 3 | Princess in the video game Monument Valley |
| 38% | ATARI | 5 | Trailblazing company in the video game industry |
| 38% | MIC | 3 | Device in the video game "Rock Band" |
| 38% | ONEAL | 5 | Shaquille in the video game "Shaq Fu" |
| 38% | CONTRA | 6 | Run and gun video game published in 1988 by Konami with the characters Bill and Lance |
| 38% | HERLOCK | 7 | ___ Sholmes, character from the video game "Ace Attorney" who was based on Sherlock Holmes |
| 38% | SIM | 3 | A person in the video game simulating life |
| 38% | DIDDY | 5 | ___ Kong, monkey character who is a sidekick to Donkey Kong in the video game franchise |