| 100% | RICE | 4 | Condoleezza who was the first female African-American secretary of state |
| 58% | MARIA | 5 | ___ Mitchell, astronomer who was the first female professor of astronomy and the first American to discover a comet |
| 58% | VIOLA | 5 | Actress Davis who was the first African American to win the Triple Crown of Acting |
| 57% | WARRENMOON | 10 | Undrafted quarterback who was the first African American quarterback inducted into the Hall of Fame: 2 wds. |
| 56% | HILLARYCLINTON | 14 | Secretary of State who was the first to visit Burma since 1955 |
| 55% | MOMSMABLEY | 10 | Trailblazing African American who was the first female comedian to perform at the Apollo Theater: 2 wds. |
| 54% | TYRA | 4 | Banks who was the first African-American woman on the cover of GQ |
| 54% | INDIRA | 6 | Gandhi who was the first female PM of India |
| 54% | TYRA | 4 | Banks who was the first African-American woman featured on the cover of "GQ" |
| 54% | ANNPRESTON | 10 | American physician and activist who was the first female dean of a medical school in the world: 2 wds. |
| 53% | PELOSI | 6 | Congresswoman Nancy who was the first female Speaker of the House |
| 52% | CANDICEBERGEN | 13 | Actress who was the first female host of "Saturday Night Live": 2 wds. |
| 52% | PATSYCLINE | 10 | American singer (birthday today) who was the first female solo artist inducted to the Country Music Hall of Fame: 2 wds. |
| 52% | RIDGE | 5 | Tom who was the first Secretary of Homeland Security |
| 52% | MOON | 4 | NFL star Warren who was the first African-American quarterback inducted into the Pro Football Hall of Fame |
| 52% | MARIECURIE | 10 | Scientist who was the first female professor at the University of Paris: 2 wds. |
| 52% | NANCYPELOSI | 11 | Democratic congresswoman from California who was the first female Speaker of the House: 2 wds. |
| 52% | CANDICEBERGEN | 13 | "Murphy Brown" star who was the first female host of "Saturday Night Live": 2 wds. |
| 51% | BUCK | 4 | O'Neil who was the first African American coach in the MLB |
| 51% | EMIL | 4 | Comedian Wakim who is the first Lebanese American cast member of "SNL" |
| 51% | DEBBIE | 6 | ___ Armstrong, former alpine skier who was the first female American skier to win an Olympic gold medal |
| 50% | POITIER | 7 | Sidney who was the first African American to win a Best Actor Oscar |
| 50% | GERE | 4 | Richard who was the first man featured on the cover of American Vogue |
| 50% | BUNCHE | 6 | Ralph who was the first African American to be awarded the Nobel Peace Prize |
| 50% | LORNASIMPSON | 12 | "Projects 23" photographer who was the first African-American woman to have a solo exhibition at the Museum of Modern Art (2 wds.) |
| 50% | ADA | 3 | Limón who is the first Latina to be Poet Laureate of the United States |
| 50% | AVA | 3 | Director DuVernay who was the first African American woman nominated for a Best Picture Oscar |
| 49% | PATSY | 5 | Cline who was the first solo female artist elected to the Country Music Hall of Fame |
| 49% | JACOBY | 6 | Ellsbury who was the first Native American of Navajo descent to play in Major League Baseball |
| 49% | ONEIL | 5 | Hall of Famer Buck who was the first African-American coach in the MLB |