| 100% | HHS | 3 | Dept. that oversees the F.D.A. |
| 64% | HHS | 3 | Dept. that oversees the FDA |
| 52% | EDUC | 4 | U.S. dept. that had a Race to the Top reform prog. |
| 50% | STARTREK | 8 | "___: Deep Space Nine," American TV series that is a spin-off of the original |
| 49% | DHS | 3 | Govt. agency that oversees the T.S.A. and FEMA |
| 49% | DOJ | 3 | Org. that oversees the FBI |
| 49% | WHITE | 5 | ___ House, residence of the POTUS in Washington, D.C. that has a colorful name |
| 48% | ETS | 3 | Co. that oversees the 21-Across |
| 48% | FIFA | 4 | Org. that oversees the World Cup |
| 48% | DHS | 3 | Agcy. that oversees the Secret Service |
| 48% | AZT | 3 | The F.D.A. approved it in 1987 |
| 48% | ARGO | 4 | 2012 film that becomes a 1996 film if you add an F at the beginning |
| 48% | WPA | 3 | Org. that oversaw F.D.R.'s Federal Project Number One |
| 47% | PGA | 3 | Group that oversees the Masters tournament: Abbr. |
| 47% | GSA | 3 | Org. that oversees the USA.gov website |
| 47% | HHS | 3 | Cabinet department that oversees the FDA: Abbr. |
| 47% | NASA | 4 | Org. that oversees the Artemis moon program |
| 47% | JUUL | 4 | Vaping brand that was targeted by the F.D.A. |
| 47% | NCAA | 4 | Organization that oversees the College World Series: Abbr. |
| 47% | INTERIOR | 8 | Cabinet department that oversees the National Park Service |
| 47% | EDUC | 4 | Dept. that oversees Pell Grants |
| 47% | HUD | 3 | Dept. that oversees Ginnie Mae |
| 47% | GMOS | 4 | They're regulated by the F.D.A. |
| 46% | EPA | 3 | Federal group that oversees the Energy Star program: Abbr. |
| 46% | NASA | 4 | Agency that oversees the moon landing project Artemis (Abbr.) |
| 46% | LUTE | 4 | Stringed instrument that becomes a woodwind instrument when an F is added to the start of its name |
| 45% | NASA | 4 | US government agency that oversees the Launch Services Program: Abbr. |
| 45% | EPA | 3 | Org. that earned a D (67 out of a possible 100) on the 2015 Center for Effective Government analysis |
| 45% | PUBLICITY | 9 | Publishing dept that hypes a book |
| 45% | DIRECTS | 7 | Oversees the filming of a movie |