| 100% | HHS | 3 | U.S. department with the motto "Improving the health, safety and well-being of America": Abbr. |
| 89% | HHS | 3 | Department with the motto "Improving the health, safety, and well-being of America": Abbr. |
| 40% | INDIANA | 7 | Midwestern US state with the motto "The Crossroads of America" |
| 38% | ACL | 3 | Part of HHS created in 2012 that aims to "maximize the independence, well-being, and health of older adults and people with disabilities" among others (abbr.) |
| 37% | MADONNA | 7 | Singer from the U.S. who is known as the "Queen of Pop" and is the best-selling female artist of all time |
| 37% | HAYS | 4 | Will H —, US politician; president of the Motion Picture Producers and Distributors of America from 1922-45 |
| 36% | EASTERNCOUGAR | 13 | A subspecies of puma from North America which was formally declared extinct by the U.S. Fish and Wildlife Service in 2018: 2 wds. |
| 35% | OSHA | 4 | Agency concerned with the well-being of employees: Abbr. |
| 35% | DAR | 3 | Organization with the motto "God, Home, and Country.": Abbr. |
| 35% | SOAPS | 5 | Galen of Pergamon described these in the 2nd century and stated the best were Germanic with Gaulish ones second best |
| 34% | NATO | 4 | Post-WWII military alliance with the U.S. and U.K.: Abbr. |
| 34% | BIBLE | 5 | With 4-Down, much of the Southeast U.S. is in it |
| 34% | BSA | 3 | Young men's organization with the motto "Be prepared": Abbr. |
| 34% | INDIANA | 7 | State with the motto “The Crossroads of America” |
| 34% | AEC | 3 | Former U.S. government agency formed for the development of atomic science and technology: Abbr. |
| 34% | SCOTT | 5 | American writer F. ___ Fitzgerald, regarded as one of the best ever from America and is known for novels like "The Great Gatsby" |
| 34% | COLIN | 5 | ___ Powell, retired general in the U. S. Army who was honored with his second Presidential Medal of Freedom in 1993 |
| 34% | UCLA | 4 | School with the motto "Let there be light": Abbr. |
| 34% | LOVEYOURSELF | 12 | Justin Bieber's acoustic pop song written by him along with Ed Sheeran and Benny Blanco which was the seventh best-selling song of 2016: 2 wds. |
| 34% | UPTON | 5 | ___ brothers, America's famous baseball siblings who were teammates with the Braves and Padres |
| 34% | NSA | 3 | Body in charge of security and surveillance in the U.S.: Abbr. |
| 34% | LOUISIANA | 9 | Southern US state with the motto "Union, Justice and Confidence" |
| 33% | NYC | 3 | US city with the Statue of Liberty: Abbr. |
| 33% | BEASHAMEDTO | 11 | With 24-, 38-, 52-, and 61-Across, Horace Mann quote that's the motto of Antioch College |
| 33% | OHIO | 4 | Home of the U.S.'s largest cities whose names start with X and Z |
| 33% | GNC | 3 | Health supplement brand with the slogan "Live Well": Abbr. |
| 33% | NSA | 3 | US intelligence organization within the Department of Defense: Abbr. |
| 33% | SNL | 3 | Show that was the source of "The Blues Brothers" and "Wayne's World": Abbr. |
| 33% | ESCORT | 6 | Ford model that was the direct replacement of the Pinto in 1981 and became the best selling car in the US |
| 33% | DIR | 3 | Jane Campion was the Oscars' best one of 2021: Abbr. |