| 100% | SHELDONCOOPER | 13 | Emmy-winning role for 41-Across: 2 wds. |
| 62% | ROSENYLUND | 10 | Emmy-winning "The Golden Girls" role for 34-Across (2 wds.) |
| 61% | JOSEPHINEBAKER | 14 | Emmy-winning title role for Lynn Whitfield in a 1991 HBO biopic about a dancer: 2 wds. |
| 61% | HANKMOODY | 9 | "Californication" role for 32-Across: 2 wds. |
| 58% | FOXMULDER | 9 | "The X-Files" role for 32-Across: 2 wds. |
| 56% | PRINCEHAMLET | 12 | Shakespearean Tony-winning stage role for 49-Across (2 wds.) |
| 54% | WINNIECOOPER | 12 | 16-Across role for 44-Across (2 wds.) |
| 53% | BITPART | 7 | Insignificant role for a secondary actor: 2 wds. |
| 51% | CENTERFIELDER | 13 | 14-Across's defensive role for most of his career: 2 wds. |
| 51% | ROBINHOOD | 9 | Role for Errol Flynn, Kevin Costner, and Russell Crowe: 2 wds. |
| 50% | ALLISONJANNEY | 13 | Actress who won Emmys for her roles on "Mom," "Masters of Sex," and "The West Wing": 2 wds. |
| 50% | HOWTOGETAWAY | 12 | With 40-Across, TV show for which 17-Across won her Emmy: 4 wds. |
| 50% | NICOLEKIDMAN | 12 | Actress who won an Emmy Award for playing Celeste on 29-Across (2 wds.) |
| 50% | BRISCOEDARLING | 14 | "The Andy Griffith Show" role for 52-Across (2 wds.) |
| 50% | UNCLEJESSE | 10 | "The Dukes of Hazzard" role for 52-Across (2 wds.) |
| 50% | EDITHBUNKER | 11 | "All in the Family" role for 31-Across (2 wds.) |
| 50% | HELLODOLLY | 10 | 2017 Broadway revival for which 41-Across won a Tony Award for Best Actress in a Musical (2 wds) |
| 50% | AMYADAMS | 8 | "Vice" actress who was nominated for an Emmy for her role in 21-Across (2 wds.) |
| 49% | SUEANNNIVENS | 12 | Emmy-winning "The Mary Tyler Moore Show" role for 34-Across (3 wds.) |
| 48% | MEGANPRICE | 10 | "Bridesmaids" role for Melissa McCarthy that was her film breakthrough: 2 wds. |
| 48% | FATHERMULCAHY | 13 | "M*A*S*H" role for William Christopher (1932-2016): 2 wds. |
| 48% | JOHNLITHGOW | 11 | Actor who won Emmys for his roles on "The Crown," "Dexter," "3rd Rock From the Sun," and "Amazing Stories": 2 wds. |
| 48% | ERICA | 5 | Emmy-winning role for Susan |
| 48% | LACEY | 5 | Emmy-winning role for Daly |
| 48% | RHODA | 5 | Emmy-winning role for Valerie |
| 48% | CARMELA | 7 | Emmy-winning role for Edie |
| 48% | DIRTYHARRY | 10 | Title role for 46-Across in a five-film franchise (2 wds.) |
| 48% | GENOAURIEMMA | 12 | Winning coach for all ten of UConn's victories: 2 wds. |
| 48% | MADMEN | 6 | Series for which Jon Hamm won an Emmy: 2 wds. |
| 48% | KISSMEKATE | 10 | 1948 Broadway show, with music and lyrics by 41-Across, that won the first Tony for Best Musical: 3 wds. |