| 100% | THEXFILES | 9 | First Fox show to finish in Nielsen's top 20 for a season |
| 33% | SRO | 3 | Like a show that's hard to get tickets for, in brief |
| 33% | RHODA | 5 | First TV show to debut at #1 in the Nielsen ratings |
| 33% | JKROWLING | 9 | First person to win a Smarties Prize, for children's books, three years in a row |
| 32% | ALSORAN | 7 | Horse that fails to finish first, second, or third in a race |
| 31% | ALSORAN | 7 | Horse that fails to finish first, second, or third in a race (Hyph.) |
| 31% | NPR | 3 | Media network for Susan Stamberg, the first woman to anchor a nightly news program in the U.S. |
| 31% | NKJEMISIN | 9 | First author to win a Hugo Award for every book in a trilogy |
| 30% | AWKWAFINA | 9 | First Asian-American woman to win a Golden Globe for lead actress in a film |
| 30% | AMYMCGRATH | 10 | First woman to fly an F/A-18 in combat for the U.S. Marine Corps |
| 29% | JOSECANSECO | 11 | First major leaguer to hit 40 homers and steal 40 bases in a season |
| 29% | TIMDUNCAN | 9 | Spurs power forward for 19 years, who was a top U.S. swimmer in the 400m freestyle before shifting to basketball: 2 wds. |
| 29% | DISQUALIFIED | 12 | Ineligible for a prize, like Maximum Security, the horse who crossed the finish line first in the 2019 29-Across |
| 29% | SYNC | 4 | Good thing for a film's audio and video to be in |
| 28% | DETROIT | 7 | First U.S. city to pave a road for cars |
| 28% | DADA | 4 | First word for many babies, to a parent's delight |
| 28% | BRYANT | 6 | Kobe ___, former Los Angeles Lakers player who was the first guard to play 20 seasons in NBA |
| 28% | IKEA | 4 | Furniture store that was the first company to show a gay couple in an American TV commercial |
| 28% | ANGELA | 6 | Bassett who was the first person to be nominated for an Oscar for acting in a Marvel movie |
| 28% | METS | 4 | M.L.B. team that was the first to trade a player for himself (Harry Chiti in 1962) |
| 28% | IMPLICATE | 9 | Show to be involved in a crime |
| 28% | ABATE | 5 | For a threat to reduce in scope |
| 28% | EPISODE | 7 | One of many showings in a TV show's season |
| 27% | MARINO | 6 | First N.F.L. QB to pass for 5,000 yards in a season |
| 27% | ALYSSANAKKEN | 12 | First woman to coach on the field of a Major League Baseball game, for the San Francisco Giants in 2020: 2 wds. |
| 27% | TVMA | 4 | Like a show that's not for kids, in short (Hyph.) |
| 27% | ARTFILM | 7 | Movie that's not likely to be shown in a multiplex |
| 27% | GRAPE | 5 | Fruit for a fox in a fable |
| 27% | ROCKETTES | 9 | Line for a show in New York? |