| 100% | THEXFILES | 9 | Fox show featuring David Duchovny and Gillian Anderson as FBI agents: 2 wds. |
| 49% | BONES | 5 | Fox show featuring David Boreanaz as an FBI agent |
| 42% | TWINPEAKS | 9 | Former ABC show featuring Kyle MacLachlan as an FBI agent: 2 wds. |
| 35% | THEXFILES | 9 | TV series in which Gillian Anderson played FBI agent Dana Scully: 2 wds., hyph. |
| 34% | THEXFILES | 9 | American sci-fi TV show starring David Duchovny, that is regarded as one of the best and is returning with its 11th season in 2018: 2 wds. |
| 32% | DANASCULLY | 10 | Gillian Anderson's skeptical FBI investigator in 43-Across: 2 wds. |
| 32% | QUANTICO | 8 | ABC show featuring Priyanka Chopra as an FBI agent |
| 32% | FOXMULDER | 9 | David Duchovny's truth-seeking FBI investigator in 43-Across: 2 wds. |
| 31% | CRIMINALMINDS | 13 | CBS drama that starred 17-Across as FBI profiler David Rossi: 2 wds. |
| 31% | THEATEAM | 8 | TV show featuring the characters Hannibal and Face: 2 wds., hyph. |
| 31% | CRIMINAL | 8 | With 18-Across, CBS show featuring Joe Mantegna as an FBI agent |
| 31% | THEATEAM | 8 | 1980s TV show featuring Mr. T as B.A. Baracus: 2 wds., hyph. |
| 28% | GLEE | 4 | Fox show featuring Rachel, Blaine, and Artie |
| 28% | SEXEDUCATION | 12 | Netflix show on which Gillian Anderson played a therapist: 2 wds. |
| 27% | SPORTSNIGHT | 11 | TV show featuring the late Robert Guillaume as Managing Editor Isaac Jaffe (2 wds.) |
| 27% | THEVIEW | 7 | Talk show featuring Meghan McCain and Whoopi Goldberg (2 wds.) |
| 27% | SPORTSNIGHT | 11 | TV show featuring Robert Guillaume as the managing editor of a TV show (2 wds.) |
| 26% | GLEE | 4 | Fox show that featured Principal Figgins and Coach Sylvester |
| 26% | XFILES | 6 | With "The," Fox show starring Gillian Anderson |
| 26% | NFLPRIMETIME | 12 | ESPN show featuring gridiron highlights: 2 wds. |
| 26% | DANA | 4 | Fox Mulder and ___ Scully, TV duo in the series "The X-Files" played by David Duchovny and Gillian Anderson |
| 26% | BUFFALOBOB | 10 | Host of the show featuring 18-Across: 2 wds. |
| 25% | CRIMINALMINDS | 13 | Long-running CBS drama in which 39-Across played an FBI agent: 2 wds. |
| 25% | JERSEYCOUTURE | 13 | Oxygen reality show featuring a family fashion boutique: 2 wds. |
| 25% | QUEEREYE | 8 | Rebooted Netflix makeover show featuring the Fab Five: 2 wds. |
| 25% | BUFFALOBILL | 11 | Frontiersman whose Wild West show featured 19-Across: 2 wds. |
| 25% | ETAL | 4 | And other people as well: 2 wds., abbr. |
| 25% | LIETOME | 7 | Former Fox show starring Tim Roth as a body language expert (3 wds.) |
| 25% | TEALEONI | 8 | "Tower Heist" actress who's married to David Duchovny: 2 wds. |
| 25% | THESIMPSONS | 11 | Animated show featuring the fast food restaurant Krusty Burger: 2 wds. |