| 100% | JAYLENO | 7 | Former "Tonight Show" host who was awarded the Mark Twain Prize in 2014: 2 wds. |
| 81% | CAROLBURNETT | 12 | Comedian and variety show host who was awarded the Mark Twain Prize in 2013: 2 wds. |
| 67% | TINAFEY | 7 | "30 Rock" star who was awarded the Mark Twain Prize in 2010: 2 wds. |
| 59% | RICHARDPRYOR | 12 | "Silver Streak" star who was awarded the very first Mark Twain Prize for American Humor in 1998: 2 wds. |
| 57% | EDDIEMURPHY | 11 | Former "Saturday Night Live" regular who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 57% | WILLFERRELL | 11 | Former "Saturday Night Live" regular who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 56% | LORNEMICHAELS | 13 | "Saturday Night Live" creator who was awarded the Mark Twain Prize for American Humor (2 wds.) |
| 54% | CONAN | 5 | O’Brien who was awarded the Mark Twain Prize for American Humor, in 2025 |
| 52% | ROBRIGGLE | 9 | Former "Daily Show" correspondent who hosted the ESPY Awards in 2012: 2 wds. |
| 52% | DAVECHAPPELLE | 13 | "A Star Is Born" actor who won the Mark Twain Prize in 2019: 2 wds. |
| 50% | LINUSPAULING | 12 | American chemist who was awarded the Nobel Peace Prize in 1962: 2 wds. |
| 49% | DAVIDLETTERMAN | 14 | Former "Late Show" host who presented Conan O'Brien with the 2025 Twain Prize: 2 wds. |
| 48% | TONIMORRISON | 12 | "Beloved" novelist who was awarded the Nobel Prize in Literature in the year 1993: 2 wds. |
| 48% | LENO | 4 | Late-night host who won the Mark Twain Prize in 2014 |
| 48% | MOTHERTERESA | 12 | Albanian-Indian catholic nun who was awarded the Nobel Peace Prize in 1979: 2 wds. |
| 47% | ADAMSANDLER | 11 | "Grown Ups" actor who won the Mark Twain Prize in 2023: 2 wds. |
| 47% | BOBDYLAN | 8 | Singer/songwriter who was awarded the 2016 Nobel Prize in Literature (2 wds.) |
| 47% | RICKILAKE | 9 | Former talk show host who premiered her documentary "Weed the People" at the SXSW festival in Austin: 2 wds. |
| 46% | NELSONMANDELA | 13 | South African anti-apartheid revolutionary who was awarded the Nobel Peace Prize in 1962: 2 wds. |
| 45% | LORNEMICHAELS | 13 | "SNL" producer who won the Mark Twain Prize for American Humor in 2004: 2 wds. |
| 45% | JIMMYFALLON | 11 | "The Tonight Show" host on the air starting in 2014: 2 wds. |
| 45% | BARACKOBAMA | 11 | 44th President of the U.S. who was awarded the Nobel Peace Prize in 2009: 2 wds. |
| 45% | WOODROWWILSON | 13 | 28th President of the U.S. who was awarded the Nobel Peace Prize in 1919: 2 wds. |
| 45% | JIMMYCARTER | 11 | 39th President of the U.S. who was awarded the Nobel Peace Prize in 2002: 2 wds. |
| 45% | BRUNOMARS | 9 | "24K Magic" singer who was the featured act in the 2014 Super Bowl halftime show: 2 wds. |
| 44% | JASONKIDD | 9 | Former NBA guard who will coach the Bucks in 2014: 2 wds. |
| 44% | DEREKFISHER | 11 | Former NBA guard who will coach the Knicks in 2014: 2 wds. |
| 44% | STEVEKERR | 9 | Former NBA guard who will coach the Warriors in 2014: 2 wds. |
| 44% | JONSTEWART | 10 | Comedian who was the host of "The Daily Show" till 2015, and has hosted 2 Grammy Award ceremonies: 2 wds. |
| 44% | BILLCOSBY | 9 | Comedian who was awarded the Spingarn Medal in 1985: 2 wds. |