| 100% | IIS | 3 | Group of Internet servers created by Microsoft for use with Windows NT family |
| 35% | CDN | 3 | System of servers created for faster Internet use: Abbr. |
| 29% | ALANON | 6 | Support group for families and friends of people with drinking problems |
| 26% | XMEN | 4 | Group of mutants created by 27-Down: Hyph. |
| 25% | PTA | 3 | Group for the families of schoolchildren: Abbr. |
| 25% | FANTASTICFOUR | 13 | Group of superheroes created by Jack Kirby and Stan Lee (2 wds.) |
| 25% | THEXMEN | 7 | Group of superheroes created by Jack Kirby and Stan Lee (2 wds.) |
| 25% | THEAVENGERS | 11 | Group of superheroes created by Jack Kirby and Stan Lee (2 wds.) |
| 25% | NEE | 3 | Used with the name of a married woman to identify former family |
| 25% | ALANON | 6 | Support group for families of drinkers |
| 24% | ADA | 3 | Group with a Seal of Acceptance for toothpaste: Abbr. |
| 24% | ASPHALT | 7 | Black by-product of petroleum used for paving |
| 23% | EFILE | 5 | Option used by 94% of US individuals for 2020 |
| 23% | PAPA | 4 | With 10-Across, sobriquet for Bill O'Reilly used by 39-Across |
| 23% | ESC | 3 | With 67-Down, tool for getting out of a window, in brief |
| 23% | DOTCOM | 6 | ___ boom ('90s event spurred by widespread use of the internet) |
| 23% | AMALGAM | 7 | Alloy of mercury with another metal, used for dental fillings |
| 22% | CAD | 3 | Software used by engineers to make sketches with help of computer (abbr) |
| 22% | ATACAMA | 7 | Region of Chile used by NASA to test equipment for Mars missions |
| 22% | YEW | 3 | A kind of wood that is used for bows (rhymes with "new") |
| 22% | JERRY | 5 | Fictional sitcom within a sitcom created by the titular character of "Seinfeld" with his friend, George Costanza |
| 22% | PEPPERS | 7 | With 15 Across, illusion that uses a reflection to create the appearance of a phantom |
| 22% | BLIGHTY | 7 | Term for England used by soldiers of the First and Second World Wars |
| 22% | HYDRO | 5 | Prefix with "power" for a method of generating 28a using fast-running water |
| 22% | POSSE | 5 | Slang for a group of people with like traits |
| 22% | EAT | 3 | Bizarre film created by Andy Warhol in 1963 consisting of Robert Indiana consuming a mushroom for 45 minutes |
| 22% | MITT | 4 | Glove used by fielders that you would need for a day of playing baseball |
| 22% | ORDER | 5 | Group of families |
| 22% | CLAN | 4 | Group of families |
| 21% | PRIDE | 5 | With 57-Across, time period honoring the group hinted at by the beginning of the starred clues |