| 100% | JOHNNYDEPP | 10 | He played one of the lead roles in the film version of 50-/55-Across |
| 46% | PRYCE | 5 | He played one of the popes in The Two Popes |
| 46% | DELTORO | 7 | He played one of the suspects in "The Usual Suspects" |
| 45% | WILLY | 5 | With 35-Across, the lead role in Arthur Miller's play "Death of a Salesman" |
| 45% | COSTAR | 6 | One of two leading actors in play or film |
| 45% | MCFLY | 5 | Lead role in the highest-grossing film of 1985 |
| 43% | DAVEEDDIGGS | 11 | Tony Award-winning actor who plays Marquis de Lafayette/Thomas Jefferson in the film version of "Hamilton" (2 wds.) |
| 43% | TIMOTHYHUTTON | 13 | "Ordinary People" actor who plays two roles in the 1993 film adaptation of 44-Across (2 wds.) |
| 43% | BATMAN&ROBIN | 12 | 1997 film with George Clooney in one of the title roles |
| 43% | PHILLIPASOO | 11 | Tony Award-nominated actress who plays Eliza Hamilton in the film version of "Hamilton" (2 wds.) |
| 42% | ELBA | 4 | He played Macavity in the 2019 movie version of Cats |
| 42% | ELIJAHWOOD | 10 | He played Frodo in "The Lord of The Rings" films |
| 42% | JONATHANGROFF | 13 | Tony Award-nominated actor who plays King George III in the film version of "Hamilton" (2 wds.) |
| 42% | JULIECHRISTIE | 13 | "Shampoo" actress who played Lara in the 1965 film version of 19-Across: 2 wds. |
| 42% | THEPACIFIER | 11 | 2005 American comedy film starring Vin Diesel in which he plays the role of U.S. Navy SEAL Shane Wolfe: 2 wds. |
| 42% | MARKWAHLBERG | 12 | Actor from "The Italian Job", who plays the lead role of Cade Yeager in 30-Across : 2 wds. |
| 42% | BEN | 3 | Actor Gazzara who played the title role of 15-Across in a 1975 film |
| 41% | NEVILLE | 7 | John —, actor who played the title role in 1988 film The Adventures of Baron Munchausen |
| 41% | LLOYD | 5 | Harold —, comedian who played the title role in 1947 film The Sin of Harold Diddlebock |
| 41% | FOX | 3 | Edward —, actor who played the title role in 1973 film drama The Day of the Jackal |
| 41% | CAVIEZEL | 8 | Jim —, actor who played the title role in 2004 film drama The Passion of the Christ |
| 41% | REID | 4 | Beryl —, actress who played the title role in 1968 film drama The Killing of Sister George |
| 41% | MRHYDE | 6 | One of two title roles (in the same film) for Spencer Tracy |
| 40% | TOD | 3 | & 11D Actor who played the title role in 1936 film drama Sweeney Todd: The Demon Barber of Fleet Street |
| 40% | USHER | 5 | One with a leading role in the theater? |
| 40% | JOHNNEVILLE | 11 | Actor who played the title role in 1988 adventure film The Adventures of Baron Munchausen |
| 40% | EBENEZER | 8 | Scrooge played by 30-Across in the 1984 version of "A Christmas Carol" |
| 39% | RENATO | 6 | Lead role in the film "La Cage aux Folles" |