| 100% | ORPHANBLACK | 11 | Hit 2010s sci-fi series in which a single actress plays multiple clones |
| 38% | DOCTORWHO | 9 | Sci-fi series in which 23-Across played Time Lord companion Amy Pond: 2 wds. |
| 36% | EVE | 3 | "Killing ___," TV series in which Sandra Oh plays a spy |
| 36% | AMEN | 4 | 1986-1991 series in which Sherman Hemsley played a church deacon |
| 35% | DOCTORWHO | 9 | BBC sci-fi series in which 31-Across plays the 10th and 14th incarnations of the title character: 2 wds. |
| 35% | GAMEOFTHRONES | 13 | American fantasy drama series in which actress from 18a plays Cersei Lannister: 3 wds. |
| 34% | ROBOT | 5 | "Mr. ___," drama thriller television series in which Rami Malek plays a cybersecurity engineer and hacker |
| 33% | KATEE | 5 | ___ Sackhoff, actress who played Kara Thrace in the sci-fi series "Battlestar Galactica" |
| 33% | MARY | 4 | ___ McDonnell, actress who played Laura Roslin in the sci-fi series "Battlestar Galactica" |
| 33% | GRACE | 5 | ___ Park, actress who played Number Eight in the sci-fi series "Battlestar Galactica" |
| 33% | AMYMANSON | 9 | Scottish actress who played Medea in 2010s BBC series Atlantis |
| 33% | THEMARTIAN | 10 | 2015 sci-fi film in which Jessica Chastain played a mission commander rescuing an astronaut: 2 wds. |
| 33% | DEBRAMESSING | 12 | Actress who played 17a in the series for which she won a Primetime Emmy Award: 2 wds. |
| 33% | STAR | 4 | "___ Trek: The Next Generation," sci-fi series in which Stephen Hawking made a guest appearance |
| 32% | BIGLITTLELIES | 13 | 2017-2019 HBO series in which Reese Witherspoon played a wealthy mom caught up in a murder case: 3 wds. |
| 32% | NASHVILLE | 9 | American musical drama series in which Steven Tyler performed a duet of Patsy Cline's "Crazy" with actress Hayden Panettiere |
| 32% | GALAXYQUEST | 11 | 1999 sci-fi comedy in which Alan Rickman played an actor from a cult TV show: 2 wds. |
| 32% | TRICIA | 6 | ___ Helfer, actress who played Number Six in the 2004 sci-fi series "Battlestar Galactica" |
| 32% | JOANOFARCADIA | 13 | 2003-2005 CBS series in which Jason Ritter played the brother of a teen tasked with a heavenly mission: 3 wds. |
| 32% | ASL | 3 | In which a single raised pinkie is an "i": Abbr. |
| 31% | OPRAHWINFREY | 12 | Actress playing Mrs. Which in "A Wrinkle in Time": 2 wds. |
| 31% | GALAXYQUEST | 11 | 1999 film in which Sigourney Weaver plays an actress who plays an officer on a spaceship: 2 wds. |
| 31% | IRIS | 4 | 2001 biopic about writer Murdoch, in which 15-Across played the title role (and received a Best Actress nomination) |
| 31% | JERRYMAGUIRE | 12 | 1996 film in which Renée Zellweger plays a single mom who falls for Tom Cruise's title character: 2 wds. |
| 30% | SOLOS | 5 | Performances in which a musician plays alone |
| 30% | SOLO | 4 | Performance in which a musician plays alone |
| 30% | MELISMA | 7 | Musical phrase in which a single syllable is sung over several notes |
| 30% | PORTLANDIA | 10 | A sketch comedy series in which Buscemi played various roles, leading to an Emmy nomination for "Outstanding Guest Actor" |
| 30% | CRASHTEST | 9 | Event in which a carmaker hit the wall? |
| 30% | GALACTICA | 9 | Titular ship in a sci-fi series |