| 100% | ORPHANBLACK | 11 | Human cloning science fiction series with a 2024 spin-off subtitled "Echoes": 2 wds. |
| 38% | SISTERBONIFACE | 14 | Wine-making Roman Catholic nun with a PhD in forensic science who first appeared on 19-Across and is now featured in a spin-off series starring 44-Across (2 wds.) |
| 35% | BLADERUNNER | 11 | 1982 science fiction film set in a dystopian future Los Angeles and about synthetic humans known as replicants: 2 wds. |
| 35% | STARTREK | 8 | Sci-fi franchise with a "Strange New Worlds" spin-off: 2 wds. |
| 34% | CSI | 3 | Series with a ''Cyber'' spin-off |
| 33% | FAMILYGUY | 9 | Fox animated series with a mother named Lois (voiced by Alex Borstein): 2 wds. |
| 33% | AQUIETPLACE | 11 | 2018 postapocalyptic horror film with a 2024 prequel subtitled "Day One": 3 wds. |
| 32% | LIVINGWITH | 10 | With 28-Across, Netflix series about a man and his clone: 2 wds. |
| 32% | CSI | 3 | Police series with a "Cyber" spin-off |
| 32% | CSI | 3 | Forensic series with a cyber spin-off |
| 32% | CURTSCHILLING | 13 | Red Sox pitcher who played in the 2004 World Series with a damaged ankle: 2 wds. |
| 31% | THEORIGINALS | 12 | The CW show starring Joseph Morgan, spun off from a supernatural drama: 2 wds. |
| 31% | FBIMOSTWANTED | 13 | 2020 crime drama spun off from a Missy Peregrym series: 3 wds. |
| 30% | FIXERUPPER | 10 | HGTV series with a 2021 Discovery+ reboot in which spouses Chip and Joanna Gaines rehab old homes: 2 wds. |
| 30% | THECROODS | 9 | 2013 animated "cave family" movie with a 2020 sequel subtitled "A New Age": 2 wds. |
| 30% | BLACKSAILS | 10 | American historical fiction series set as a prequel to Robert Stevenson's "Treasure Island": 2 wds. |
| 30% | STARWARS | 8 | Sci-fi franchise with the new spin-off TV series, 38-Across: 2 wds. |
| 30% | STEVENYEUN | 10 | Korean American "Minari" actor honored with a 2024 Great Immigrants award: 2 wds. |
| 30% | ARIANAGRANDE | 12 | "7 Rings" singer who reimagined 18-Across in a 2024 hit with the same title: 2 wds. |
| 29% | FRANKIEADAMS | 12 | Actress who plays the role of Bobbie Draper in the science fiction TV series "The Expanse": 2 wds. |
| 29% | BETTYFORD | 9 | 1970s US First Lady who was honored with a 2024 US postage stamp: 2 wds. |
| 29% | JOHNNYBRAVO | 11 | Popular animated TV series with a boorish, muscular young man as its titular character who tries to get women to date him: 2 wds. |
| 27% | NCISNEWORLEANS | 14 | 2014 spin-off of a long-running Mark Harmon series: 3 wds. |
| 27% | DAVIDPRICE | 10 | Red Sox pitcher who won two games in the 2018 World Series with a 1.98 ERA (2 wds.) |
| 27% | DRIVETO | 7 | With 37-Across, subtitle of a hit Netflix documentary series about Formula 1 racing (2 wds.) |
| 27% | AROOM | 5 | "___ With a View" (1985 movie): 2 wds. |
| 27% | SALSA | 5 | Dance with a series of spins |
| 27% | TIESDOWN | 8 | Secures with a rope: 2 wds. |
| 27% | TIEON | 5 | Attach with a rope: 2 wds. |
| 27% | GRINAT | 6 | Greet with a smile: 2 wds. |