| 100% | IRENEADLER | 10 | Holmes character created by Arthur Conan Doyle who may be modeled after Lillie Langtry or Lola Montez |
| 37% | SHERLOCK | 8 | ___ Holmes, fictional detective created by Arthur Conan Doyle, who you may associate with 20a, 33a, 42a, 9d, and 36d |
| 30% | SHERLOCK | 8 | ___ Holmes, fictional detective created by Arthur Conan Doyle |
| 29% | IRENE | 5 | Adler created by Arthur Conan Doyle |
| 28% | IRENEADLER | 10 | Opera singer created by Arthur Conan Doyle |
| 28% | LESTRADE | 8 | Fictional Scotland Yard inspector in stories by Arthur Conan Doyle involving Sherlock Holmes who first appeared in A Study in Scarlet |
| 28% | SHERLOCKHOLMES | 14 | Fictional detective created by Arthur Conan Doyle: 2 wds. |
| 27% | SHERLOCK | 8 | __ Holmes, character by Sir Arthur Conan Doyle |
| 26% | SILVERBLAZE | 11 | 1892 story by Arthur Conan Doyle featuring detective Sherlock Holmes |
| 26% | SIGNOFFOUR | 10 | The —, 1890 novel by Arthur Conan Doyle featuring Sherlock Holmes |
| 25% | BELL | 4 | Joseph ___, surgeon whom Arthur Conan Doyle cites as inspiration for the character of Sherlock Holmes |
| 25% | STONE | 5 | "Rodney ___," gothic mystery novel by Arthur Conan Doyle that was adapted as "The House of Temperley" |
| 24% | POLE | 4 | "The Captain of the ___-Star," short story by Arthur Conan Doyle that was published in the Temple Bar |
| 23% | HOLMES | 6 | Sherlock ___, Sir Arthur Conan Doyle's brilliant detective who is never seen without his signature deerstalker hat |
| 23% | LOST | 4 | "The ___ World," first book featuring the character of Professor Challenger created by Arthur Conan Doyle |
| 22% | FINAL | 5 | "The ___ Problem," Sherlock Holmes short story by Arthur Conan Doyle |
| 22% | THEDOINGSOF | 11 | & 25A 1892 novel by Arthur Conan Doyle |
| 22% | LANDOFMIST | 10 | The —, 1926 novel by Arthur Conan Doyle |
| 22% | MICAH | 5 | & 21A 1889 novel by Arthur Conan Doyle |
| 22% | SCANDAL | 7 | "A ___ in Bohemia," Sherlock Holmes short story by Arthur Conan Doyle |
| 22% | PIPS | 4 | "The Five Orange ___," Sherlock Holmes short story by Arthur Conan Doyle |
| 21% | BAKERSTREET | 11 | & 1A Group of street urchins who aid Sherlock Holmes in various stories by Arthur Conan Doyle |
| 21% | POSSE | 5 | Followers who may be friendly or hostile |
| 21% | HEIR | 4 | One who might be apparent or presumptive |
| 21% | CHARMING | 8 | Prince who might be pleasant or disagreeable |
| 21% | LIAR | 4 | Person who might be "compulsive" or "pathological" |
| 21% | IRENE | 5 | ___ Adler, iconic character from the Sherlock Holmes stories who was played by Lara Pulver on screen |