| 100% | IRENEADLER | 10 | Fictional opera singer/actress who outsmarts Sherlock Holmes in the Arthur Conan Doyle story "A Scandal in Bohemia" (2 wds.) |
| 46% | LESTRADE | 8 | Fictional Scotland Yard inspector in stories by Arthur Conan Doyle involving Sherlock Holmes who first appeared in A Study in Scarlet |
| 40% | SCANDAL | 7 | "A ___ in Bohemia," Sherlock Holmes short story by Arthur Conan Doyle |
| 39% | FINAL | 5 | & 16A The —, Sherlock Holmes story by Arthur Conan Doyle first published in the Strand Magazine in December 1893 |
| 38% | BAKERSTREET | 11 | & 1A Group of street urchins who aid Sherlock Holmes in various stories by Arthur Conan Doyle |
| 36% | NANETTEFABRAY | 13 | Actress and singer (1920-2018) who won a Tony in 1949 and three Emmys in the 1950s: 2 wds. |
| 35% | WILLFERRELL | 11 | "Anchorman" actor who plays Sherlock Holmes in the upcoming movie "Holmes & Watson": 2 wds. |
| 35% | IRENE | 5 | Adler of the Sherlock Holmes story “A Scandal in Bohemia” |
| 35% | SARAHPAULSON | 12 | "American Horror Story" actress who won the 2024 Best Leading Actress in a Play Tony for "Appropriate": 2 wds. |
| 35% | KATRINALENK | 11 | 30-Across singer/actress who won the 2018 Tony Award for Best Actress in a Musical (2 wds.) |
| 35% | ZOESALDANA | 10 | "Avatar" actress who played a pirate in the first "Pirates of the Caribbean" film: 2 wds. |
| 34% | SUTTONFOSTER | 12 | "Younger" actress who played Princess Winnifred in the 2024 Broadway revival of "Once Upon a Mattress": 2 wds. |
| 34% | STUDY | 5 | "A ___ in Scarlet" (first Sherlock Holmes novel by Arthur Conan Doyle) |
| 34% | THEWEEKND | 9 | "Starboy" pop singer who had 18 songs on the Billboard Hot 100 during a week in 2016: 2 wds. |
| 34% | DEBRAMESSING | 12 | Actress who played 17a in the series for which she won a Primetime Emmy Award: 2 wds. |
| 34% | MINDYKALING | 11 | "The Office" actress who owns a stake in the Swansea City Association Football Club: 2 wds. |
| 34% | DREWBARRYMORE | 13 | American singer SZA's song which is titled after a "Charlie's Angels" actress who also makes a cameo in the music video: 2 wds. |
| 33% | KIRSTENDUNST | 12 | "The Power of the Dog" actress who plays a journalist in the new movie "Civil War": 2 wds. |
| 33% | KATHYBATES | 10 | Actress who plays a marijuana dispensary owner in the new Netflix comedy "Disjointed": 2 wds. |
| 33% | MORIARTY | 8 | Professor James —, arch-enemy of Sherlock Holmes in stories by Arthur Conan Doyle |
| 33% | MERYLSTREEP | 11 | "Into the Woods" actress who plays a feminist in 42-Across: 2 wds. |
| 33% | MARGOTROBBIE | 12 | Actress who plays a fictional associate producer in "Bombshell": 2 wds. |
| 33% | RACHELMCADAMS | 13 | "True Detective" actress who played 32-Across in the Guy Ritchie film "Sherlock Holmes" (2 wds.) |
| 33% | SELENAGOMEZ | 11 | Actress and singer who voiced Mavis Dracula in the 2012 animated film "Hotel Transylvania": 2 wds. |
| 33% | BEVERLYSILLS | 12 | Opera singer who chaired Lincoln Center and received the National Medal of Arts in 1990: 2 wds. |
| 33% | BELL | 4 | Joseph ___, surgeon whom Arthur Conan Doyle cites as inspiration for the character of Sherlock Holmes |
| 33% | LIVTYLER | 8 | "Armageddon" actress who played the lead singer's girlfriend Faye in 34-Across: 2 wds. |
| 32% | BAND | 4 | "The Adventure of the Speckled ___," Sherlock Holmes short story by Arthur Conan Doyle |
| 32% | JULIANNEMOORE | 13 | Actress who plays an activist aiding a pregnant woman in a dystopian retelling of the nativity story in "Children of Men" (2 wds.) |
| 32% | SELENAGOMEZ | 11 | "Only Murders in the Building" actress who received a kidney transplant in 2017: 2 wds. |