| 100% | IRENEADLER | 10 | Opera singer created by Arthur Conan Doyle |
| 67% | IRENE | 5 | Adler created by Arthur Conan Doyle |
| 66% | SHERLOCK | 8 | ___ Holmes, fictional detective created by Arthur Conan Doyle |
| 65% | SHERLOCKHOLMES | 14 | Fictional detective created by Arthur Conan Doyle: 2 wds. |
| 61% | LOST | 4 | "The ___ World," first book featuring the character of Professor Challenger created by Arthur Conan Doyle |
| 60% | IRENEADLER | 10 | Holmes character created by Arthur Conan Doyle who may be modeled after Lillie Langtry or Lola Montez |
| 59% | SHERLOCK | 8 | ___ Holmes, fictional detective created by Arthur Conan Doyle, who you may associate with 20a, 33a, 42a, 9d, and 36d |
| 54% | THEDOINGSOF | 11 | & 25A 1892 novel by Arthur Conan Doyle |
| 54% | LANDOFMIST | 10 | The —, 1926 novel by Arthur Conan Doyle |
| 54% | MICAH | 5 | & 21A 1889 novel by Arthur Conan Doyle |
| 50% | SILVERBLAZE | 11 | 1892 story by Arthur Conan Doyle featuring detective Sherlock Holmes |
| 50% | SIGNOFFOUR | 10 | The —, 1890 novel by Arthur Conan Doyle featuring Sherlock Holmes |
| 50% | FINAL | 5 | "The ___ Problem," Sherlock Holmes short story by Arthur Conan Doyle |
| 50% | STUDY | 5 | "A ___ in Scarlet" (first Sherlock Holmes novel by Arthur Conan Doyle) |
| 50% | SCANDAL | 7 | "A ___ in Bohemia," Sherlock Holmes short story by Arthur Conan Doyle |
| 50% | FOUR | 4 | "The Sign of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 50% | BASKERVILLES | 12 | "The Hound of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 50% | PIPS | 4 | "The Five Orange ___," Sherlock Holmes short story by Arthur Conan Doyle |
| 49% | MORIARTY | 8 | Professor James —, archenemy of Sherlock Holmes in tales by Arthur Conan Doyle |
| 49% | VALLEY | 6 | "The Mystery of the Sasassa ___," first published work by Arthur Conan Doyle |
| 48% | BAND | 4 | "The Adventure of the Speckled ___," Sherlock Holmes short story by Arthur Conan Doyle |
| 48% | MORIARTY | 8 | Professor James —, arch-enemy of Sherlock Holmes in stories by Arthur Conan Doyle |
| 47% | LOT | 3 | "___ No. 249," gothic horror short story by Arthur Conan Doyle that influenced the Mummy horror genre |
| 47% | STONE | 5 | "Rodney ___," gothic mystery novel by Arthur Conan Doyle that was adapted as "The House of Temperley" |
| 47% | BAKERSTREET | 11 | & 1A Group of street urchins who aid Sherlock Holmes in various stories by Arthur Conan Doyle |
| 46% | ASTUDYIN | 8 | & 16D First of four Sherlock Holmes novels by Arthur Conan Doyle, published in book form in 1888 |
| 45% | POLE | 4 | "The Captain of the ___-Star," short story by Arthur Conan Doyle that was published in the Temple Bar |