| 100% | INAREA | 6 | How Alaska is first among the states |
| 82% | INAREA | 6 | How Alaska ranks first among the states |
| 46% | DEMOCRAT | 8 | Among presidents, Jackson was the first |
| 44% | LANDAREA | 8 | Alaska's is the largest of the 50 states |
| 44% | ONE | 3 | How old a baby is after the first birthday |
| 43% | AREA | 4 | Alaska's ranks first among states |
| 42% | DEANE | 5 | Silas who was the United States' first foreign diplomat (1776) |
| 41% | SPARSELY | 8 | How Alaska is populated |
| 41% | VERMONT | 7 | State whose last four letters are the first four letters of its capital |
| 41% | RICE | 4 | Condoleezza who was the first female African-American secretary of state |
| 41% | DOUG | 4 | Emhoff who will be the first Second Gentleman of the United States |
| 41% | ASH | 3 | Cigarette remains (and how the first syllable of 50-Across is pronounced) |
| 41% | HILLARYCLINTON | 14 | Secretary of State who was the first to visit Burma since 1955 |
| 40% | LAURABUSH | 9 | Former Girl Scout who was First Lady of the United States from 2001 to 2009 (2 wds.) |
| 40% | MICHELLEOBAMA | 13 | Former Girl Scout who was First Lady of the United States from 2009 to 2017 (2 wds.) |
| 40% | JOHNBROWN | 9 | *Abolitionist who was the first person executed for treason in the United States |
| 40% | TOPEKA | 6 | Capital whose last two letters are the first two letters of its state |
| 40% | YORK | 4 | New ___, state where Buffalo was the first city to host a Turkey Trot |
| 39% | MASSACHUSETTS | 13 | State whose General Court was the first to recognize Fourth of July as a state celebration |
| 39% | ADA | 3 | Limón who is the first Latina to be Poet Laureate of the United States |
| 39% | AKITA | 5 | Japanese breed that Helen Keller is credited with first bringing to the United States |
| 39% | JACKIEKENNEDY | 13 | Former First Lady of the United States who was born in July (2 wds.) |
| 39% | JILLBIDEN | 9 | Former Girl Scout who is the current First Lady of the United States (2 wds.) |
| 39% | SARAHPALIN | 10 | In 2006, she became the first woman to be elected governor of Alaska: 2 wds. |
| 39% | KOSOVO | 6 | Partially-recognized Balkan state that was a first time entrant at the 2016 Summer Olympics |
| 38% | DEL | 3 | Its nickname is "the First State": Abbr. |
| 38% | LED | 3 | Was first on the trail |
| 38% | OBESITY | 7 | The state of being overweight |
| 38% | FREEDOM | 7 | The state of being liberated |
| 38% | EXISTENCE | 9 | The state of being alive |