| 100% | RAIDER | 6 | Lara Croft is the main character in Tomb __ |
| 59% | JUNGLE | 6 | Mowgli is the main character in The __ Book |
| 58% | MACAW | 5 | The main character in "Rio" is one |
| 57% | OYL | 3 | Olive ___ who was the main character in "Thimble Theatre" before Popeye |
| 56% | SEURAT | 6 | Artist who is the main character in "Sunday in the Park With George" |
| 56% | PENNYWISE | 9 | Evil clown who is the main character in Stephen King's novel "It" |
| 55% | APE | 3 | What the main character in "Mighty Joe Young" was |
| 55% | ANNA | 4 | ___ and Elsa, princess duo who are the main characters in Disney's "Frozen" series |
| 55% | EPISODEONE | 10 | The main characters are usually introduced in it |
| 52% | TOMBRAIDER | 10 | Franchise whose main character is Lara Croft |
| 49% | FRY | 3 | The main character in "Futurama" |
| 48% | RYU | 3 | Main character in Capcom's Street Fighter series whose "special move" was the subject of a scientific work last year |
| 48% | RAPUNZEL | 8 | __ is the main character of Tangled |
| 48% | SEINFELD | 8 | Sitcom whose four main characters are convicted of a crime in the final episode |
| 47% | EMOTIONS | 8 | The main characters in “Inside Out,” e.g. |
| 47% | TEDMOSBY | 8 | The main character in How I Met Your Mother |
| 47% | SALESMEN | 8 | The main characters in "Glengarry Glen Ross," by trade |
| 47% | FIGHTCLUB | 9 | Tyler Durden is the main character of __ |
| 47% | CHANCE | 6 | Christopher, the main character in Human Target |
| 46% | GAY | 3 | Like the main characters in "Fire Island" |
| 46% | LITTLEWOMEN | 11 | Louisa May Alcott classic whose main characters are hidden in the answers to the starred clues |
| 46% | PROSPERO | 8 | Main character in The Tempest |
| 46% | VEEP | 4 | Sitcom in which the main character's political party is never identified |
| 46% | BELLA | 5 | ___ Swan, the main character in the "Twilight" series |
| 46% | OWLBOY | 6 | Platform game; flying Otus is the main character |
| 46% | ASH | 3 | Main character in the "Pokémon" series |
| 45% | OHARA | 5 | Scarlett ___, the main character in "Gone with the Wind" |
| 45% | CHARLIE | 7 | With 47-Across, the main character in 15-Across |
| 45% | SKYWALKER | 9 | Last name of the main character in Star Wars |
| 45% | CROMWELL | 8 | Thomas, the main character in Mantel's Wolf Hall |