| 100% | SOUP | 4 | Liquid served as the first course |
| 66% | SOUP | 4 | Liquid food usually served in the first course |
| 63% | OPEN | 4 | Serve as the first act |
| 57% | ASTOR | 5 | Nancy who served as the first female member of the British Parliament |
| 55% | KWAME | 5 | ___ Nkrumah, Ghanaian politician who served as the first Prime Minister and President of Ghana |
| 54% | PATRICELUMUMBA | 14 | Pan-Africanist who served as the first Prime Minister of the Democratic Republic of the Congo |
| 53% | LOVE | 4 | "New ___," song by Dua Lipa which served as the first single of her self-titled debut album |
| 52% | SOUP | 4 | Watery dish often served as a first course |
| 49% | RENO | 4 | Janet who was the first woman to serve as U.S. attorney general |
| 47% | UNDERLIE | 8 | Serve as the basis for |
| 46% | SOUPSAYWEALL | 12 | Unanimous vote on the first course? |
| 46% | EPITOMIZE | 9 | Serve as the ideal example of |
| 46% | ABET | 4 | Serve as the getaway driver for, say |
| 45% | TOSSASALAD | 10 | Prepare the first course, say |
| 45% | TOIL | 4 | Sweat as the first lubricant |
| 45% | JANETRENO | 9 | First woman to serve as attorney general of the US: 2 wds. |
| 45% | PIEPAN | 6 | Tin tossed as the first Frisbee |
| 45% | PETER | 5 | Saint recognized as the first Pope |
| 44% | SAUCES | 6 | Thick liquids served as accompaniment to food |
| 44% | SOUP | 4 | Often the first course of a meal |
| 44% | PERICLES | 8 | Known as the first citizen of Athens |
| 44% | ADA | 3 | Lovelace, recognized as the first computer programmer |
| 44% | ADALOVELACE | 11 | Mathematician regarded as the first computer programmer |
| 44% | WISK | 4 | The first liquid laundry detergent |
| 44% | RENO | 4 | Janet, first woman to serve as the Attorney General of the United States |
| 43% | CHU | 3 | Steven ___, Nobelist who served as the Energy Secretary |
| 43% | RAHM | 4 | Emanuel who served as the mayor of Chicago |
| 43% | ELLA | 4 | Fitzgerald known as the First Lady of Song |
| 43% | ASONANT | 7 | Not voiced, as the first "d" in "Wednesday" |
| 43% | ACTED | 5 | Served as hero in the film |