| 100% | OSCARWAO | 8 | Novel title character with a "brief, wondrous life" |
| 53% | ELOISE | 6 | Title character with a pug named Weenie |
| 52% | NED | 3 | Title character with a "Declassified School Survival Guide" |
| 52% | MOESHA | 6 | Sitcom title character with a diary |
| 51% | ADA | 3 | Literary title character with a palindromic name |
| 51% | DRMARIO | 7 | Nintendo title character with a head mirror |
| 50% | NED | 3 | Nickelodeon title character with a Declassified School Survival Guide |
| 48% | EXORCIST | 8 | Title character of a Blatty novel |
| 47% | CARRIE | 6 | Title character in a Theodore Dreiser novel |
| 47% | LORDJIM | 7 | Title character in a Joseph Conrad novel |
| 46% | ANNIE | 5 | Musical with a preteen title character |
| 46% | LADYINWHITE | 11 | 1988 movie with a ghostly title character |
| 45% | ANNAKARENINA | 12 | Title character in a love triangle with two men named Alexei |
| 45% | BAMBI | 5 | Cartoon title character adapted from a Felix Salten novel |
| 45% | HEYARNOLD | 9 | Nickelodeon cartoon with a nine-year-old title character |
| 43% | GATSBY | 6 | Title character of classic American literature who is obsessed with a green light |
| 43% | BESS | 4 | Opera title character who's initially in a relationship with Crown |
| 43% | ANNA | 4 | Title character of literature in a love triangle with two 66-Across named Alexei |
| 43% | THEBLACKPANTHER | 15 | Comic book character with the title role in a blockbuster 2018 film |
| 42% | SEA | 3 | Title setting for a Hemingway novel, with "the" |
| 42% | SEA | 3 | Title locale for a Hemingway novel, with "the" |
| 42% | ADA | 3 | Nabokov novel with a palindromic title |
| 42% | FATHER | 6 | Play based on a Clarence Day novel: Life With __ |
| 42% | EASTOFEDEN | 10 | Steinbeck novel with a title from Genesis |
| 41% | ALF | 3 | TV series from the 80s with a friendly extraterrestrial creature playing the title character |
| 41% | LORAX | 5 | Dr. Seuss title character voiced by Danny DeVito in a 2012 film, with "The" |
| 41% | BEES | 4 | Insects with "secret lives," per a Sue Monk Kidd title |
| 41% | LORNA | 5 | ___ Doone (cookie brand that shares its name with a character from a Victorian romance novel) |
| 41% | JUNOTDIAZ | 9 | "The Brief Wondrous Life of Oscar Wao" author who was awarded a MacArthur Fellowship "genius grant" in 2012: 2 wds. |
| 40% | BLACKBEAUTY | 11 | Classic novel with a chapter titled "My Breaking In" |