| 100% | USN | 3 | Org. founded in response to Barbary pirates |
| 50% | NCAA | 4 | Org. formed in response to football injuries |
| 48% | TMI | 3 | Response to oversharing found in this puzzle's starred answers |
| 48% | NBA | 3 | Org. found in the answer to each asterisked clue |
| 46% | UNICEF | 6 | Org. established in response to the refugee crisis that followed the Second World War |
| 45% | PAIN | 4 | Aptly named advocacy org. founded by Nan Goldin in response to the opioid crisis |
| 44% | EPA | 3 | Org. established partly in response to Rachel Carson's "Silent Spring" |
| 42% | WINCESAT | 8 | Flinches in response to |
| 41% | REACTS | 6 | Acts in response to something |
| 41% | ACTSON | 6 | Takes steps in response to |
| 41% | ACTON | 5 | Do something in response to |
| 41% | REACT | 5 | Show emotion in response to something |
| 41% | AREYOU | 6 | Question in response to "I am" |
| 41% | PARENTSTRIKE | 12 | Walkout in response to unruly kids? |
| 41% | ILLGETIT | 8 | Words in response to a doorbell |
| 41% | ENCORE | 6 | Extra performance in response to applause |
| 41% | ANSWERS | 7 | Solutions given in response to questions |
| 41% | BOW | 3 | Bend over in response to applause |
| 41% | ARENTI | 6 | Smug question in response to praise |
| 40% | GOA | 3 | Org, founded in 1975 that, according to its website, has "never wavered from its mission to defend the Second Amendment" (abbr.) |
| 40% | AMI | 3 | Question in response to an insult, maybe |
| 40% | REFLEX | 6 | Involuntary movement in response to a stimulus |
| 40% | AMEN | 4 | Word shouted in response to a pastor |
| 40% | CANCELCULTURE | 13 | Controversial phenomenon in response to controversial actions |
| 40% | WHOWANTSTOKNOW | 14 | Sassy question in response to a question |
| 40% | OAS | 3 | Org. founded in 1948 |
| 40% | DAR | 3 | Org. founded in 1890 |
| 40% | EPA | 3 | Org. founded in 1970 |
| 40% | OOF | 3 | Response to "pow!" in cartoons |
| 40% | AYE | 3 | Response to "All in favor" |