| 100% | JOHNNYGALECKI | 13 | Portrayer of Leonard Hofstadter on 42-Across: 2 wds. |
| 71% | JIMPARSONS | 10 | Portrayer of Sheldon Cooper on 42-Across: 2 wds. |
| 67% | KALEYCUOCO | 10 | Portrayer of Penny on 42-Across: 2 wds. |
| 58% | CHEVYCHASE | 10 | Portrayer of Pierce Hawthorne on 16-Across: 2 wds. |
| 58% | JOELMCHALE | 10 | Portrayer of Jeff Winger on 16-Across: 2 wds. |
| 58% | MARILYNMONROE | 13 | Portrayer of Sugar Kane in 42-Across: 2 wds. |
| 53% | TONYCURTIS | 10 | Portrayer of Joe and Josephine in 42-Across: 2 wds. |
| 53% | JACKLEMMON | 10 | Portrayer of Jerry and Daphne in 42-Across: 2 wds. |
| 53% | SOFIAVERGARA | 12 | Portrayer of Gloria Delgado-Pritchett on 14-Across: 2 wds. |
| 53% | SCOTTBAKULA | 11 | Portrayer of physicist Sam Beckett on 40-Across: 2 wds. |
| 52% | AARONPAUL | 9 | Portrayer of Jesse Pinkman on "Breaking Bad": 2 wds. |
| 51% | CLAIREDANES | 11 | Emmy-winning portrayer of Carrie Mathison on 16-Across: 2 wds. |
| 51% | DAMIANLEWIS | 11 | Emmy-winning portrayer of Nicholas Brody on 16-Across: 2 wds. |
| 51% | DEANSTOCKWELL | 13 | Portrayer of Al Calavicci, a holographic sidekick on 40-Across: 2 wds. |
| 49% | KARLURBAN | 9 | Portrayer of Dr. Leonard McCoy in "Star Trek Into Darkness": 2 wds. |
| 49% | JOHNTRAVOLTA | 12 | Portrayer of Robert Shapiro on "American Crime Story": 2 wds. |
| 49% | SARAHPAULSON | 12 | Portrayer of Marcia Clark on "American Crime Story": 2 wds. |
| 48% | ALANALDA | 8 | Portrayer of Hawkeye Pierce on "M*A*S*H": 2 wds. |
| 48% | JOHNMAHONEY | 11 | Portrayer of Martin Crane on "Frasier" who died February 4: 2 wds. |
| 47% | KATEMULGREW | 11 | Portrayer of Galina Reznikov (a.k.a. "Red") on "Orange Is the New Black": 2 wds. |
| 45% | MICHELLEYEOH | 12 | Portrayer of Evelyn Wang in "Everything Everywhere All at Once" and Guanyin on "American Born Chinese": 2 wds. |
| 45% | JAMESHONG | 9 | Portrayer of Gong Gong in "Everything Everywhere All at Once" and Jade Emperor on "American Born Chinese": 2 wds. |
| 45% | STEPHANIEHSU | 12 | Portrayer of Joy Wang in "Everything Everywhere All at Once" and Shiji Niangniang on "American Born Chinese": 2 wds. |
| 45% | MARTINSHEEN | 11 | Portrayer of 29-Across: 2 wds. |
| 44% | MORGANFREEMAN | 13 | Portrayer of 52-Across in 15-Across: 2 wds. |
| 44% | AMYSEDARIS | 10 | Voice of Princess Carolyn on 36-Across: 2 wds. |
| 43% | JULIANNEMOORE | 13 | Portrayer of 14-Across' spouse in "The Kids Are All Right": 2 wds. |
| 43% | JAMESSPADER | 11 | Portrayer of Raymond Reddington (a.k.a. "Red") on "The Blacklist": 2 wds. |
| 41% | MORGANFREEMAN | 13 | Portrayer of Nelson Mandela in "Invictus": 2 wds. |
| 41% | FRANKLANGELLA | 13 | Portrayer of Dracula in "Dracula" (1979): 2 wds. |