| 100% | META | 4 | Prefix with physics to form a branch of abstract philosophy |
| 51% | ORTHO | 5 | Prefix with "pedics" to mean a branch of medicine |
| 49% | ACU | 3 | Prefix with "pressure" to mean a form of alternative medicine |
| 49% | ACU | 3 | Prefix with "puncture" to mean a form of traditional Chinese medicine |
| 41% | WHIRL | 5 | Prefix with "pool" to mean a spinning mass of water |
| 41% | HEMI | 4 | Prefix with "sphere" to mean half of a sphere |
| 41% | GEO | 3 | Prefix with "metry" for a branch of mathematics |
| 41% | AVI | 3 | Prefix with "fauna" to mean birds of a particular region |
| 40% | ACU | 3 | Prefix with "puncture" for a form of alternative medicine |
| 40% | ACU | 3 | Prefix with "pressure" for a form of alternative medicine |
| 40% | MONO | 4 | Prefix with "chromatic" to indicate the use of a single color |
| 40% | ACRO | 4 | Prefix with "phobia" to mean a fear of heights |
| 40% | IDEO | 4 | Prefix with "logy" to mean a set of beliefs |
| 40% | PAIN | 4 | Prefix with "killer" to mean a type of pill |
| 40% | STAIR | 5 | Prefix with "case" to mean a set of steps |
| 40% | STAIR | 5 | Prefix with "case" to mean a series of steps |
| 39% | ACRO | 4 | Prefix with "yoga" to mean the practice that involves a lot of lifting |
| 39% | ASTRO | 5 | Prefix with 19d that is a branch of science popularized by people like Stephen Hawking and Neil deGrasse Tyson |
| 38% | ECTO | 4 | Prefix with "plasm" to mean a layer of a cell's cytoplasm |
| 38% | ADO | 3 | Suffix with color to form the name of a U.S. state |
| 37% | MONO | 4 | Prefix with chrome to mean "of a single color" |
| 36% | GEO | 3 | Prefix with physics, related to the Earth |
| 36% | GEOMETRY | 8 | A branch of mathematics that deals with shapes |
| 35% | PARABOLA | 8 | Symmetrical curve formed by the intersection of a cone with a plane parallel to its side |
| 35% | TRI | 3 | Prefix with "ceratops" to mean a dinosaur |
| 35% | SCREW | 5 | Prefix with "driver" to mean a tool |
| 35% | NEO | 3 | Prefix with "phyte" to mean a beginner |
| 35% | SCREW | 5 | Prefix with "driver" to mean a cocktail |
| 35% | AERO | 4 | Prefix with plane, to a Brit |
| 35% | NEO | 3 | Prefix with "natal," to a pediatrician |