| 100% | MORIARTY | 8 | Professor James —, arch-enemy of Sherlock Holmes in stories by Arthur Conan Doyle |
| 75% | MORIARTY | 8 | Professor James —, archenemy of Sherlock Holmes in tales by Arthur Conan Doyle |
| 59% | LESTRADE | 8 | Fictional Scotland Yard inspector in stories by Arthur Conan Doyle involving Sherlock Holmes who first appeared in A Study in Scarlet |
| 58% | SCANDAL | 7 | "A ___ in Bohemia," Sherlock Holmes short story by Arthur Conan Doyle |
| 56% | BAND | 4 | "The Adventure of the Speckled ___," Sherlock Holmes short story by Arthur Conan Doyle |
| 55% | BAKERSTREET | 11 | & 1A Group of street urchins who aid Sherlock Holmes in various stories by Arthur Conan Doyle |
| 54% | SILVERBLAZE | 11 | 1892 story by Arthur Conan Doyle featuring detective Sherlock Holmes |
| 52% | FINAL | 5 | "The ___ Problem," Sherlock Holmes short story by Arthur Conan Doyle |
| 52% | FINAL | 5 | & 16A The —, Sherlock Holmes story by Arthur Conan Doyle first published in the Strand Magazine in December 1893 |
| 51% | PIPS | 4 | "The Five Orange ___," Sherlock Holmes short story by Arthur Conan Doyle |
| 50% | ASTUDYIN | 8 | & 16D First of four Sherlock Holmes novels by Arthur Conan Doyle, published in book form in 1888 |
| 47% | IRENEADLER | 10 | Fictional opera singer/actress who outsmarts Sherlock Holmes in the Arthur Conan Doyle story "A Scandal in Bohemia" (2 wds.) |
| 46% | SIGNOFFOUR | 10 | The —, 1890 novel by Arthur Conan Doyle featuring Sherlock Holmes |
| 44% | SIR | 3 | ___ Arthur Conan Doyle (title for the creator of Sherlock Holmes) |
| 44% | STUDY | 5 | "A ___ in Scarlet" (first Sherlock Holmes novel by Arthur Conan Doyle) |
| 43% | PASTICHE | 8 | Sherlock Holmes story not by Conan Doyle, e.g. |
| 43% | POLE | 4 | "The Captain of the ___-Star," short story by Arthur Conan Doyle that was published in the Temple Bar |
| 43% | FOUR | 4 | "The Sign of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 43% | BASKERVILLES | 12 | "The Hound of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 42% | BELL | 4 | Joseph ___, surgeon whom Arthur Conan Doyle cites as inspiration for the character of Sherlock Holmes |
| 38% | LOT | 3 | "___ No. 249," gothic horror short story by Arthur Conan Doyle that influenced the Mummy horror genre |
| 38% | FINAL | 5 | "The ___ Problem," Sherlock Holmes story that was originally intended by Arthur Conan Doyle to be his last Holmes-related work |
| 37% | ADLER | 5 | Irene in a short story by Sir Arthur Conan Doyle |
| 36% | STONE | 5 | "Rodney ___," gothic mystery novel by Arthur Conan Doyle that was adapted as "The House of Temperley" |
| 36% | IRENEADLER | 10 | Holmes character created by Arthur Conan Doyle who may be modeled after Lillie Langtry or Lola Montez |
| 36% | MORIARTY | 8 | Arch-enemy of Sherlock Holmes |
| 35% | HAWKEYE | 7 | Alias of Natty Bumppo in stories by James Fenimore Cooper |
| 34% | DOYLE | 5 | Arthur Conan ___ (creator of Sherlock Holmes) |
| 34% | SHERLOCK | 8 | Detective in an Arthur Conan Doyle book: __ Holmes |
| 34% | SHERLOCK | 8 | ___ Holmes, fictional detective created by Arthur Conan Doyle |