| 100% | STARTREK | 8 | Sci-fi franchise featuring 39-Across as Spock (2 wds.) |
| 67% | TRANSFORMERS | 12 | Sci-fi franchise featuring 39-Across as the voice of Sentinel Prime |
| 48% | STARWARS | 8 | Sci-fi film franchise featuring Han Solo and Princess Leia (2 wds.) |
| 45% | THEHUNGERGAMES | 14 | Film franchise featuring 42-Across as Master of Ceremonies Caesar Flickerman (3 wds.) |
| 41% | THEMATRIX | 9 | Sci-fi movie franchise starring Keanu Reeves: 2 wds. |
| 41% | ICEAGE | 6 | Animated movie franchise featuring a mammoth named Manny: 2 wds. |
| 40% | STARWARS | 8 | George Lucas's hugely popular sci-fi film franchise (2 wds) |
| 39% | STARWARS | 8 | 1977 movie that launched a huge sci-fi franchise: 2 wds. |
| 38% | STARWARS | 8 | Sci-fi franchise with the new spin-off TV series, 38-Across: 2 wds. |
| 38% | DEVIOUSMAIDS | 12 | Lifetime TV series starring 39-Across as a house cleaner in Beverly Hills (2 wds.) |
| 38% | HALO | 4 | Sci-fi franchise that started as an Xbox game |
| 38% | STARTREK | 8 | American sci-fi franchise including Mr. Spock |
| 38% | THEORVILLE | 10 | Sci-fi TV series created by and starring Seth MacFarlane as Captain Ed Mercer (2 wds.) |
| 38% | STARWARS | 8 | 1977 George Lucas film that launched a sci-fi franchise: 2 wds. |
| 37% | STARTREK | 8 | Sci-fi franchise with a "Strange New Worlds" spin-off: 2 wds. |
| 37% | LITTLEWOMEN | 11 | 1994 film featuring 31-Across as the mother of four daughters (2 wds.) |
| 37% | THECROWN | 8 | Netflix historical drama featuring 47-Across as Camilla Parker Bowles (2 wds.) |
| 37% | TRANSFORMERS | 12 | Film franchise featuring 42-Across as Merlin and Joshua Joyce |
| 37% | STAR | 4 | * "___ Wars," sci-fi franchise that features beings like 11a |
| 36% | DWAYNEJOHNSON | 13 | Star of 39-Across, also known as "The Rock": 2 wds. |
| 36% | COVERTAFFAIRS | 13 | USA series featuring Piper Perabo as Annie Walker: 2 wds. |
| 36% | MYSONGS | 7 | 2019 remix and greatest hits album by 39-Across featuring 18-Across and 25-Across (2 wds.) |
| 36% | ICEAGE | 6 | Animated film franchise featuring the voice of Ray Romano (2 wds.) |
| 35% | ICEAGE | 6 | Animated film franchise featuring a saber-toothed tiger named Diego (2 wds.) |
| 35% | LORENZOSOIL | 11 | 1992 film featuring 31-Across as the mother of a boy with a rare disease (2 wds.) |
| 34% | PARTIII | 7 | See 39-Across: 2 wds. |
| 34% | DESPICABLEME | 12 | Film franchise featuring yellow Minions with its second sequel in 2017 (2 wds.) |
| 34% | CHAOSWALKING | 12 | Sci-fi thriller starring Daisy Ridley, Tom Holland, and 44-Across (2 wds.) |
| 34% | GIJOE | 5 | Sci-fi film based on a toy franchise, "___: The Rise of Cobra": 3 wds. |
| 34% | DESPICABLEME | 12 | Film franchise featuring yellow Minions with sequels in 2013, 2017, and 2024 (2 wds.) |