| 100% | ACER | 4 | Serena Williams, often |
| 65% | TENNIS | 6 | Serena Williams' sport |
| 63% | LOB | 3 | Serena Williams defensive shot |
| 63% | SIS | 3 | Serena Williams, to Venus |
| 62% | RACKET | 6 | Serena Williams' on-court weapon |
| 59% | RACKET | 6 | Serena Williams hits the ball with this |
| 59% | LITTLESISTERS | 13 | Serena Williams and Naomi Osaka, e.g. |
| 59% | ACE | 3 | Perfect serve from Serena Williams |
| 59% | ESPY | 4 | 2019 award for Serena Williams |
| 59% | WTA | 3 | Organization for Serena Williams: Abbr. |
| 58% | GOAT | 4 | Superlative acronym often applied to Serena Williams or Wayne Gretzky |
| 58% | NET | 3 | What often comes between Venus and Serena Williams? |
| 57% | GRANDSLAM | 9 | Serena Williams won 23 of these tennis titles |
| 57% | WTA | 3 | Org. for Venus and Serena Williams |
| 57% | SISTERS | 7 | Venus and Serena Williams, e.g. |
| 57% | LOB | 3 | High, arcing shot from Serena Williams |
| 57% | LOB | 3 | High-hit shot from Serena Williams |
| 56% | OLYMPICMEDALIST | 15 | Muhammad Ali or Serena Williams, e.g. |
| 56% | ESPY | 4 | Award won by Serena Williams 11 times |
| 56% | WOMENSSINGLES | 13 | Category for Serena Williams and Naomi Osaka |
| 56% | USOPEN | 6 | Tournament Serena Williams has won six times |
| 54% | MATCH | 5 | Tennis ___ (best-of-three competition for Serena Williams) |
| 54% | TENNIS | 6 | Sport played by Serena Williams and Rafael Nadal |
| 54% | AGEGAP | 6 | Just one year, for Venus and Serena Williams |
| 54% | TENNIS | 6 | Game played by Serena Williams and Rafael Nadal |
| 54% | ESPY | 4 | Award won by Simone Biles and Serena Williams |
| 54% | ESPY | 4 | Athletic award won 12 times by Serena Williams |
| 54% | SISTER | 6 | Venus Williams, to Serena |
| 53% | ALEXIS | 6 | Name of Serena Williams's first-born and husband |
| 50% | LAWNTENNIS | 10 | Formal name for the game played by Venus and Serena Williams |