| 100% | FAMILYGUY | 9 | Seth MacFarlane animated series featuring the voices of 15-Across, 26-Across, and 34-Across that debuted in 1999 (2 wds.) |
| 56% | FAMILYGUY | 9 | Animated TV series featuring the voices of Seth MacFarlane and 43-Across (2 wds.) |
| 56% | FAMILYGUY | 9 | Animated TV series featuring the voices of Seth MacFarlane and 42-Across (2 wds.) |
| 46% | THEXFILES | 9 | Paranormal TV series featuring the characters 15-Across, 21-Across, and 41-Across that debuted in 1993 (2 wds.) |
| 45% | SAILORMOON | 10 | Manga series that debuted in 1992 featuring 18-Across, 25-Across, 34-Across, and schoolgirl Usagi Tsukino who transforms into the title character (2 wds.) |
| 41% | HARLEYQUINN | 11 | HBO Max animated series, about the Joker's ex-girlfriend, that features the voice of Alan Tudyk: 2 wds. |
| 41% | WRECKITRALPH | 12 | 2012 animated film featuring the voices of John C. Reilly and Sarah Silverman: 2 wds. |
| 41% | CARMENSANDIEGO | 14 | Netflix animated adventure series featuring the voice of 49-Across as the title character (2 wds.) |
| 40% | MELBLANC | 8 | The voice of 15-Across and many other Looney Tunes characters: 2 wds. |
| 39% | THECROODS | 9 | 2013 animated film set in the Pliocene Era featuring the voice of 43-Across (2 wds.) |
| 39% | STEVENUNIVERSE | 14 | Cartoon Network animated series that featured Susan Egan as the voice of the Crystal Gems' former leader Rose Quartz (2 wds.) |
| 38% | KINGOFTHE | 9 | US animated television series featuring the voice talent of Mike Judge and Kathy Najimy that ran from 1997-2010 |
| 37% | SPINCITY | 8 | Political sitcom starring Barry Bostwick, 15-Across, 20-Across, and 37-Across that debuted in 1996 (2 wds.) |
| 37% | BOSTONREDSOX | 12 | 15-Across team that traded away 45-Across in 1919 and endured the "Curse of the Bambino" until winning the World Series in 2004 (3 wds.) |
| 37% | THEWILDROBOT | 12 | 2024 animated film featuring the voices of Pedro Pascal, 14-Across, and 31-Across about an automaton who befriends animals on a remote island (3 wds.) |
| 37% | IAMNOTAN | 8 | & 6D 2004 BBC TV animated comedy series featuring the voice talent of Steve Coogan and Amelia Bullmore |
| 36% | TEDDYBEAR | 9 | Stuffed animal that Seth MacFarlane provided the voice for in a hit 2012 movie: 2 wds. |
| 36% | KUNGFU | 6 | "___ Panda," 2008 animated movie featuring the voice of Jack Black: 2 wds. |
| 36% | ASTROBOY | 8 | Manga-based animated film featuring the voice of 28-Across as a robot named Mr. Squeegee (2 wds.) |
| 36% | KING | 4 | "The Lion ___," animated movie featuring voices of Beyonce and Seth Rogen that was one of the biggest hits of 2019 |
| 36% | BOBSBURGERS | 11 | Fox animated sitcom that once featured the voice of "Mad Men" star Jon Hamm as a toilet (2 wds.) |
| 36% | UGLYDOLLS | 9 | Animated film featuring a brand of plush toys and the voices of 15-Across and 33-Across |
| 36% | SIDNEYPOITIER | 13 | Star of 15- and 34-Across who won an Oscar for "Lilies of the Field": 2 wds. |
| 35% | AMERICANDAD | 11 | Animated show in which the father (voiced by Seth MacFarlane) works for the CIA: 2 wds. |
| 35% | KILLINTIME | 10 | Album by 45-Across featuring the singles 18-Across and 26-Across that won the 1989 Album of the Year Academy of Country Music Award (2 wds.) |
| 35% | WILLSMITH | 9 | "King Richard" actor who also starred in 15-Across, 26-Across, and 34-Across (2 wds.) |
| 35% | COMICBOOK | 9 | Setting for each of the places in 15-, 21-, and 41-Across: 2 wds. |
| 35% | THEFLINTSTONES | 14 | Television series set in Bedrock that debuted in 1960 as the first animated series to run in prime time (2 wds.) |
| 34% | CENTURYCYCLE | 12 | Series of 10 plays by 14-Across, including "Fences" and "The Piano Lesson," that chronicle life in Black America over a 100-year span: 2 wds. |