| 100% | CHRISTIAN | 9 | Slater who plays the title character in "Mr. Robot" |
| 68% | TOM | 3 | Hiddleston who plays the title character in Loki |
| 68% | TIERNEY | 7 | Gene who played the title character in Laura |
| 68% | TAMARA | 6 | Dobson who played the title character in “Cleopatra Jones” |
| 67% | TOMHARDY | 8 | "Inception" actor who plays the title character in "Venom": 2 wds. |
| 67% | MARGOTROBBIE | 12 | "Babylon" actress who plays the title character in "Barbie": 2 wds. |
| 67% | PESCI | 5 | Actor Joe who played the title character in "My Cousin Vinny" |
| 67% | RIK | 3 | Comedian Mayall who played the title character in Drop Dead Fred |
| 66% | ROBERTDENIRO | 12 | "Joy" actor who plays the title character in 18-Across: 3 wds. |
| 65% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 65% | KATEY | 5 | With 35-Across, "Sons of Anarchy" actress who plays the title character in "Rebel" |
| 65% | FERDIASHAW | 10 | Young actor who plays the title character in the 2020 movie "Artemis Fowl": 2 wds. |
| 65% | PETERDINKLAGE | 13 | "Game of Thrones" actor who plays the title character in "The Toxic Avenger": 2 wds. |
| 65% | SARAHPAULSON | 12 | "American Horror Story" actress who plays the title character in Netflix's "Ratched": 2 wds. |
| 65% | WHITE | 5 | Carol —, actress who played the title character in 1966 BBC TV play Cathy Come Home |
| 65% | EVA | 3 | Actress Green who played the title character in "Miss Peregrine's Home for Peculiar Children" |
| 64% | HANDL | 5 | Irene —, comedy actress who played the title character in 1970s ITV sitcom For the Love of Ada |
| 63% | GARY | 4 | English actor ___ Oldman who played the title character in the movie adapted from Bram Stoker's novel "Dracula" |
| 63% | ADAM | 4 | Driver who plays the title character's brother in the heist caper "Logan Lucky" |
| 62% | RACHELMCADAMS | 13 | "Doctor Strange" actress who plays the title character's mom in 33-/49-Across: 2 wds. |
| 61% | JAMESMCAVOY | 11 | "X-Men: Apocalypse" star who played the title character of 28-Across in a 2015 movie: 2 wds. |
| 60% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 58% | JEREMYPIVEN | 11 | US actor who played the title role in ITV drama series Mr Selfridge |
| 57% | MICHAELCIMINO | 13 | "Annabelle Comes Home" actor who plays the newly out title character in "Love, Victor": 2 wds. |
| 57% | KENNETHBRANAGH | 14 | Actor who directed and played the title character in 1996's "Hamlet": 2 wds. |
| 56% | MILA | 4 | She played the title character in Black Swan |
| 56% | TARONEGERTON | 12 | "Kingsman: The Golden Circle" actor who plays the title character in 16-Across: 2 wds. |
| 56% | PETER | 5 | & 25A Comedy actor who played the title role in ITV sitcom Mr Digby Darling |
| 56% | NIELSEN | 7 | Leslie —, actor who played the title role in 1997 film comedy Mr Magoo |