| 100% | ITIS | 4 | Suffix used in medicine to name inflammations |
| 45% | OPS | 3 | Suffix used in taxonomy when naming species that means "face", from the ancient Greek |
| 45% | EARDROP | 7 | Medicine used in your ear to prevent infections |
| 42% | STARZ | 5 | Movie channel that used to have an "!" in its name |
| 42% | NESTLES | 7 | Brand name that used to be spelled out in commercials |
| 41% | EST | 3 | Suffix used in exaggerations |
| 41% | KESHA | 5 | "Blow" singer who used to have a dollar sign in her name |
| 41% | EGAD | 4 | Shout once used to avoid taking 6-Down's name in vain |
| 40% | LEECH | 5 | Worm used in medicine |
| 40% | LEECH | 5 | Parasite used in medicine |
| 40% | KESHA | 5 | One-named singer who used to have a dollar sign in her name |
| 40% | KESHA | 5 | "Tik Tok" singer who used to have a dollar sign in her name |
| 39% | LDOPA | 5 | Psychoactive drug used in medicine |
| 39% | RADIATION | 9 | Electromagnetic energy used in medicine |
| 39% | EST | 3 | Powerful suffix used in superlatives |
| 39% | OLAY | 4 | Skin care brand that used to have "Oil of" in front of its name |
| 39% | LABRAT | 6 | Name given to a rodent used in experimentation |
| 39% | HERB | 4 | Type of plant used in medicine |
| 39% | GINGER | 6 | Spice used in medicines, teas, foods |
| 38% | ONEARMEDMAN | 11 | Name used to refer to Frederick Sykes, the main suspect according to the protagonist in 18a: 2 wds. |
| 38% | ESE | 3 | Suffix used in languages spoken in China or Japan |
| 38% | ESERINE | 7 | Alkaloid used in medicine, known as physostigmine |
| 38% | MUCILAGE | 8 | Gelatinous substance from plants used in medicine |
| 38% | DEXTROSE | 8 | Simple sugar made from corn used in medicine |
| 38% | HERB | 4 | Type of plant used in medicine and cooking |
| 38% | MORPHINE | 8 | Opiate used in medicine for strong pain relief |
| 38% | LEECH | 5 | Blood-sucking worm that was used in medicine |
| 37% | EQUATION | 8 | Used in math to solve problems |
| 37% | AER | 3 | Name of the large veil used to cover the bread and wine for the Eucharist in the Eastern Orthodox Church |
| 37% | EST | 3 | Suffix used frequently in "Guinness World Records" |